Effect of nicardipine on blood flow of deep inferior epigastric artery in patients undergoing breast reconstruction

Effect of nicardipine on blood flow of deep inferior epigastric artery in patients undergoing breast reconstruction using deep inferior epigastric perforator flap: a randomized, double-blind, placebo-controlled study

Status

Unknown

Phases

Phase 4

Study type

Interventional

Source

CRIS

Registry ID

KCT0005015

Enrollment

110

Registered

2020-05-13

Start date

2020-06-25

Completion date

Unknown

Last updated

2021-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : According to the allocated group, nicardipine or normal saline is used. Nicardipine is applied 0.5 mg (0.5 cc) into the adventitial layer of the deep inferior epigastric artery at 5 minutes aft

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1) After mastectomy with breast cancer, patients having breast reconstruction using deep inferior epigastric perforator flap 2) 20 years old = age < 80 years 3) Patients who voluntarily consent to this clinical study

Exclusion criteria

Exclusion criteria: 1) Patients with hypersensitivity to nicardipine 2) Patients with acute heart failure, aortic valve stenosis, mitral stenosis, hypertrophic obstructive cardiomyopathy, hypotension 3) Patients with abnormal liver function 4) Patients with abnormal renal function 5) Pregnant and lactating women 6) Refusal of patient

Design outcomes

Primary

Measure	Time frame
Blood flow of deep inferior epigastric artery after deep inferior epigastric artery and internal mammary artery are anastomosed.	—

Secondary

Measure	Time frame
Free flap failure rate;Free flap failure rate;Hospital stay	—

Countries

Korea, Republic of

Contacts

Public Contactjihion Yu

Asan Medical Center

Outcome results