The effect of epinephrine used for upper extremity anesthesia on preventing hypotension during sedation using dexmedetomidine

The effect of epinephrine as an adjuntive agent for brachial plexus block on preventing hypotension during sedation using dexmedetomidine: a randomized controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0004961

Enrollment

130

Registered

2020-04-27

Start date

2020-05-01

Completion date

Unknown

Last updated

2021-10-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : A single brachial plexus block is performed before the surgery. Drug used for regional anesthesia is as follows. - Control group: 1% lidocaine 12cc + 0.75% ropivacaine 12cc + NSS 1cc = 25cc -

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. age 20 ~ 65 year 2. American society of anesthesiologist physical status1~2 3. Upper extremity surgery 4. use of regional anesthesia with intraoperative sedation

Exclusion criteria

Exclusion criteria: 1. other than supine position, intraoperatively 2. allergy to local anesthetics, epinephrine, dexmedetomidine 3. coagulopathy or local infection in block site 4. unable to use epinephrine or dexmedetomidine due to hemodynamic cause (uncontrolled hypertension, tachycardia, bradycardia) 5. patient refusal

Design outcomes

Primary

Measure	Time frame
Occurrence of hypotension during and after the surgery (mBP < 60mmHg or <75% of baseline, sBP <90mmHg or <75% of baseline)	—

Secondary

Measure	Time frame
Occurrence of bradycardia during and after the surgery (< 75% of baseline and <50 bpm);Maximum hemodynamic reduction during and after surgery (sBP, dBP, mBP, HR);Drug use due to hemodynamic compromise during and after surgery;length of post-anesthesia care unit stay (minutes);first request of analgesics after surgery (minutes, first dose of patient-controlled analgesia pump);cumulative dose of opioid during first 24hrs after surgery (fentanyl, mcg; PCA pump record review);other complication than hemodynamics	—

Measure

Time frame

Occurrence of bradycardia during and after the surgery (< 75% of baseline and <50 bpm);Maximum hemodynamic reduction during and after surgery (sBP, dBP, mBP, HR);Drug use due to hemodynamic compromise during and after surgery;length of post-anesthesia care unit stay (minutes);first request of analgesics after surgery (minutes, first dose of patient-controlled analgesia pump);cumulative dose of opioid during first 24hrs after surgery (fentanyl, mcg; PCA pump record review);other complication than hemodynamics

—

Countries

Korea, Republic of

Contacts

Public ContactChahyun Oh

Chungnam National University Hospital

5chahyun@naver.com+82-42-280-7844

Outcome results