A randomized controlled trial evaluating the effect of exercise intervention on cardiovascular health and metabolic biomarkers in middle-aged and elderly community-dwelling persons with metabolic disorders.

The effects of exercise training on vascular endothelial function and metabolic-related biomarkers: a community-based exercise intervention study

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0004951

Enrollment

100

Registered

2020-04-21

Start date

2016-09-15

Completion date

Unknown

Last updated

2020-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Behavioral : Exercise intervention group (Experimental group) Exercise Program: Designed with reference to exercise management guidelines (American Sports Medicine Association) and clinical exercise p

) and gradually increasing the intensity of exercise, exercise awareness 13 ~ 16 during the 4th week of exercise training (maximum heart rate 60 ~ 75&#37

). Measurement of exercise intensity and exercise volume by monitoring heart rate to some subjects every two weeks. Aerobic exercise program mainly using the step platform is implemented. - Strength t

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Adults 18 years of age or older and metabolic syndrome: Risk group of metabolic syndrome based on International Diabetes Federation (IDF) criteria ? Abdominal obesity: waist circumference =90 cm for men, =80 cm for women (based on East Asians) or BMI is> 30 kg / m² ? systolic / diastolic blood pressure =130 / 85 mmHg ? Fasting blood sugar =100 mg / dL or those diagnosed with type 2 diabetes ? Neutral lipid> 150 mg / dL or dyslipidemia diagnosis ? High-density cholesterol <40 mg / dL for men, <50 mg / dL for women or those with experience in treatment with dyslipidemia diagnosis

Exclusion criteria

Exclusion criteria: ? People who have diseases other than hypertension, diabetes, dyslipidemia, or are taking medications to treat other diseases. ? A person who has undergone surgical treatment due to a fracture or damage to the musculoskeletal system within the last 6 months. ? Those who participated in regular exercise more than 2 times per week on average and 1 hour per week within the last 6 months. ? Those who have been deemed unsuitable by other research directors as subjects of this study.

Design outcomes

Primary

Measure	Time frame
reactive hyperemia index (RHI);augmentation index (AI);the components of metabolic syndrome (waist circumference, body mass index, blood pressure, fasting glucose, triglyceride, HDL-cholesterol);serum levels of cytokines (myokines, adipokines, hepatokines, osteokines etc.);blood chemistry (ALT, AST, GGT, blood creatinine, Hb-A1C, insulin)	—

Secondary

Measure	Time frame
health-related physical fitness (muscular endurance and strength, agility, aerobic capacity, balance, flexibility etc.);body composition (body fat mass, lean body mass);bone stiffness index	—

Countries

Korea, Republic of

Contacts

Public ContactJae Seung Chang

Yonsei University Wonju College of Medicine

Outcome results