None listed
Conditions
Interventions
None listed
Sponsors
Asan Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Age 19-79 years 2) Thyroid nodules sized 6-10 mm by ultrasound within three months 3) Thyriod nodules confirmed by fine needle biopsy guided ultrosound or core needle biopsy as having Bethesda category V or VI cytology (or histopathology) within 1 year. : If cytology (or histopathology) showed Bethesda category V, the nodule should show high suspicion ultrasound features by K-TIRADS system or have BRAF V600E mutation.
Exclusion criteria
Exclusion criteria: 1) People who have difficulty understanding the study (e.g. an illiterate, decreased vision) 2) Pregnant 3) People having other chronic disease or other uncontrolled cancers - Excluding eGFR<30mL/min/1.73m2 - Other condition can be enrolled if it doesn't affect PTMC treatment progress and result by the investigator's decision. 4) People who need total thyroidectomy due to multiple nodules or other thyroid disease 5) Thyroid nodules showing (suspecting) metastases, invasion to extrathyroidal organs, bronchus, muscles or nurves(vocal cords paralysis)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Progression Free Survival | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall survival according to the treatment;Risk factors of disease progression during active surveillance: age, sex, and ultrasound features;Proportion of patients who change their treatment option from active surveillance to surgery without disease progression: Analyze reasons for changing of mind by questionnaires;Changes in quality of life questionnaire scores according to the treatment and follow-up periods;Cost-effective analysis according to the treatment;Surgical outcomes analysis according to the treatment: Extent of surgery, complications of surgery;Appropriate courses(intervals) for imaging during active surveillance | — |
Countries
Korea, Republic of
Contacts
Public ContactYunJung Kim
Asan Medical Center
Outcome results
None listed