None listed
Conditions
Interventions
Drug : For type 2 diabetes patients with insufficient blood glucose control with metformin and sulfonlyurea 2 therapy, the drug is 1:1 randomly assigned to the group Dulaglutide (GLP-1 receptor agonis
Sponsors
Kyung Hee University Hosipital at Gangdong
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Adults between 20 and 75 years of age diagnosed with type 2 diabetes 2) Patients with poor control of blood sugar level of 7.0% or more of HbA1c even though metformin and sulfone urea were used in combination for more than 2 months 3) Those who voluntarily agreed to participate in the study
Exclusion criteria
Exclusion criteria: a. If you have a liver disease of a specific cause, such as viral hepatitis, autoimmune hepatitis, alcoholic liver disease b. Drug users who can affect blood sugar, fatty liver, and gut microflora (Within 3 months from the study start date) -Glycocorticoid -Nonsteroidal anti-inflammatory -Immunosuppressive -All kinds of antibiotics -DPP4 inhibitors -alpha glucosidase inhibitors -Probiotics -Hepatotonics, including UDCA c. If the laboratory test results below are abnormal -estimated GFR <30 ml / min / 1.73 m2 d. Drug abuser e. Pregnant and lactating women f. People on dialysis for terminal renal failure g. Beneficiaries of organ transplants, including the liver h. Those who have undergone surgery to modify the structure of the intestine (eg gastrointestinal resection) i. 30g men a day, 20g women or more drinkers j. Those who have received clinical trial drugs within the last 3 months k. In addition, those judged to be impossible to participate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in severity of fatty liver | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in body mass index, waist circumference and body mass;Comparison before and after treatment of fasting blood glucose, glycated albumin, glycated hemoglobin;internal fat area change;Changes in insulin resistance and secretion;Change of Lipid profile;Change of AST, ALT, Total bilirubin;Change of hs-crp, leptin, adiponectin, TNF-a, IL-6;Change of primary bile acid and secondary bile acid;Comparison of microbial cluster changes in intestinal excretion | — |
Countries
Korea, Republic of
Contacts
Public Contactjunghwa Lee
Kyung Hee University Hosipital at Gangdong
Outcome results
None listed