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Risk stratification by genetic mutation in dilated cardiomyopathy

Genetic test based risk stratification of sudden cardiac death and progression to end-stage heart failure in patients with dilated cardiomyopathy

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
CRIS
Registry ID
KCT0004913
Enrollment
200
Registered
2020-04-13
Start date
2020-03-19
Completion date
Unknown
Last updated
2020-04-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

None listed

Sponsors

Yonsei University Health System, Gangnam Severance Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Inclusion criteria: 1) or 2) with 3) 1) Non-ischemic dilated cardiomyopathy with functional class II or more and persistently reduced left ventricular ejection fraction of 35% or less than 35% even after medical treatment at least 3 months. (regardless of ICD or CRT implantation) 2) Patients with dilated cardiomyopathy who underwent ICD implantation as a secondary prevention purpose and left ventricular ejection fraction less than 50% even after medical treatment. 3) Patients with age of 19 to 85 years who agree to study enrollment.

Exclusion criteria

Exclusion criteria: 1) Patients with expected survival duration is within 6 months due to cancer or cerebrovascular disease. 2) Patients with dilated cardiomyopathy which related to neuromuscular disease 3) Patients who can't understand study purpose due to cognitive dysfunction or unstable hemodynamic status.

Design outcomes

Primary

MeasureTime frame
Sudden cardiac death or admission due to heart failure aggrevation or death due to heart failure aggrevation or cardiac transplatation or left ventricular assist device implantation due to progression to end-stage heart failure

Secondary

MeasureTime frame
Appropriate anti-tachycardia pacing or appropriate ICD shock or ventricular tachycardia or ventricular fibrillation or new onset atrial fbrillation detected in EGM

Countries

Korea, Republic of

Contacts

Public ContactMinjee Kim

Yonsei University Health System, Gangnam Severance Hospital

Outcome results

None listed

Source: CRIS (via WHO ICTRP) · Data processed: Feb 4, 2026