Glycopyrrolate and one lung ventilation oxygenation

Efficacy of Glycopyrrolate Premedication on Oxygenation in Patients Undergoing One-lung Ventilation

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0004909

Enrollment

104

Registered

2020-04-10

Start date

2020-05-08

Completion date

Unknown

Last updated

2020-04-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : In control group, normal saline 1ml will be injected preoperatively. In experimental group, glycopyrrolate 0.2 mg will be injected preoperatively.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients with informed consent 2. Patients scheduled for lung resection under one lung ventilation after general anesthesia

Exclusion criteria

Exclusion criteria: 1. American anesthesiologist society physical status classification > III 2. Patients with symptom or severe obstructive or restrictive lung disease 3. Patients with preoperative oxygen therapy 4. Patients undergoing preoperative intubation or mechanical ventilation 5. Patients with preoperative arterial oxygen tension < 70 mmHg 6. Patients with symptoms of coronary arterial disease or peripheral vascular disease 7. Patients with renal failure 8. Patients with preoperative inotropics or vasopressors 9. Patients with pregnancy

Design outcomes

Primary

Measure	Time frame
Arterial oxygen tension at 30 min after one lung ventilation	—

Secondary

Measure	Time frame
Arterial oxygen tension at 20 min after two lung ventilation and 60 min after one lung ventilation;Arterial carbon dioxide tension at 20 min after two lung ventilation and 30, 60 min after one lung ventilation;Propofol infusion concentration at 20 min after two lung ventilation and 30, 60 min after one lung ventilation;Remifenatnil infusion concentration at 20 min after two lung ventilation and 30, 60 min after one lung ventilation;Mean blood pressure at 20 min after two lung ventilation and 30, 60 min after one lung ventilation;Heart rate at 20 min after two lung ventilation and 30, 60 min after one lung ventilation;Body temperature at 20 min after two lung ventilation and 30, 60 min after one lung ventilation;Central venous pressure at 20 min after two lung ventilation and 30, 60 min after one lung ventilation;Cardiac index at 20 min after two lung ventilation and 30, 60 min after one lung ventilation;Peak pressure of ventilation at 20 min after two lung ventilation and 30, 60 min after one lung ventilation;Plateau pressure of ventilation at 20 min after two lung ventilation and 30, 60 min after one lung ventilation;Arterial oxygen saturation at 20 min after two lung ventilation and 30, 60 min after one lung ventilation;Arterial pH at 20 min after two lung ventilation and 30, 60 min after one lung ventilation;Arterial base excess at 20 min after two lung ventilation and 30, 60 min after one lung ventilation	—

Measure

Time frame

Arterial oxygen tension at 20 min after two lung ventilation and 60 min after one lung ventilation;Arterial carbon dioxide tension at 20 min after two lung ventilation and 30, 60 min after one lung ventilation;Propofol infusion concentration at 20 min after two lung ventilation and 30, 60 min after one lung ventilation;Remifenatnil infusion concentration at 20 min after two lung ventilation and 30, 60 min after one lung ventilation;Mean blood pressure at 20 min after two lung ventilation and 30, 60 min after one lung ventilation;Heart rate at 20 min after two lung ventilation and 30, 60 min after one lung ventilation;Body temperature at 20 min after two lung ventilation and 30, 60 min after one lung ventilation;Central venous pressure at 20 min after two lung ventilation and 30, 60 min after one lung ventilation;Cardiac index at 20 min after two lung ventilation and 30, 60 min after one lung ventilation;Peak pressure of ventilation at 20 min after two lung ventilation and 30, 60 min after one lung ventilation;Plateau pressure of ventilation at 20 min after two lung ventilation and 30, 60 min after one lung ventilation;Arterial oxygen saturation at 20 min after two lung ventilation and 30, 60 min after one lung ventilation;Arterial pH at 20 min after two lung ventilation and 30, 60 min after one lung ventilation;Arterial base excess at 20 min after two lung ventilation and 30, 60 min after one lung ventilation

—

Countries

Korea, Republic of

Contacts

Public ContactHyun-Chang Kim

Korea University Anam Hospital

Outcome results