None listed
Conditions
Interventions
Others : In the control group, general lung protective ventilation is performed, and the positive end-expiratory pressure is fixed to 5 cm H2O). In the intervention group, positive end-expiratory pres
Sponsors
Seoul National University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients who are 18 years of age or older and who undergo major surgery under pneumoperitoneum with Trendelenburg position, who have a moderate or higher risk of developing postoperative pulmonary complications were included.
Exclusion criteria
Exclusion criteria: 1) open surgery 2) American Society of Anesthesiologists physical status classification = 3 3) in case of patients with acute respiratory distress syndrome before surgery or patients with history of acute respiratory distress syndrome 4) body mass index = 35 kg/m2 5) in case of patients with angina, heart failure or suspicion of increased intracranial pressure 6) in case of patients with pneumothorax or giant bullae 7) other contraindications for applying positive end-expiratory pressure (bronchopleural fistula, hypovolemic shock, right ventricular failure, etc) 8) pregnant woman 9) surgery performed at the prone position, lateral position, or reverse Trendelenburg position
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the incidence of postoperative pulmonary complications (atelectasis, SpO2 = 92%(room air), acute respiratory distress syndrome, pneumonia, pleural effusion, bronchospasm, pneumothorax, aspiration pneumonia, early extubation failure or requirement of reintubation, postoperative requirements for rescue maneuvers) | — |
Secondary
| Measure | Time frame |
|---|---|
| arterial blood gas analysis;other postoperative complications (heart failure, wound infection, wound dehiscence, sepsis, acute kidney injury [determined by Kidney Disease Improving Global Outcomes{KDIGO} creatinine criteria], surgical reintervention, etc);clinical outcome (length of hospital stay, intensive care unit admission, length of intensive care unit stay);respiratory variables during intraoperative mechanical ventilation | — |
Countries
Korea, Republic of
Contacts
Public ContactHyun-Kyu Yoon
Seoul National University Hospital
Outcome results
None listed