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Development of biomarkers for phenotype classification toward precision medicine in obstructive sleep apnea

Development of biomarkers for phenotype classification toward precision medicine in obstructive sleep apnea

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CRIS
Registry ID
KCT0004885
Enrollment
2000
Registered
2020-04-03
Start date
2018-11-22
Completion date
Unknown
Last updated
2023-12-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

None listed

Sponsors

Chonnam National University Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Teens and adults over the age of 15 Patients with suspected sleep apnea with Apnea-hypopnea index 5 or higher on polysomnography A person who voluntarily agrees in writing to participate in this study

Exclusion criteria

Exclusion criteria: Pregnant women, women who may be pregnant, and women who breastfeed Patients with central sleep apnea or other sleep disorders such as insomnia, restless leg syndrome, lethargy, circadian disorder, and event sleep before medical treatment Patients with diseases of moderate or higher lung disease, neuromuscular disease, heart failure, etc., which may decrease the accuracy of sleep polysomnography Patients who do not agree to surveys and polysomnography

Design outcomes

Primary

MeasureTime frame
Biomarker : C-reactive protein, Interleukin-6, Interleukin-8, Interleukin-10, tumor necrosis factor-a, Intercellular adgesion-1, Vascular cell adgesion-1, L-selectin, HemoglovinA1c, Uric acid, Erythroprotein, Leptin, Resistin;Obesity related factor : height, weight, neck circumference, Body Mass Index;Facial anatomy : cephalometry, neck computed tomography;drug-induced sleep endoscopy;rain imaging : MRI/A(Magnetic resonance imaging/Angiography), PET(Positron emission tomography) or SPECT(Single Photon emission computed tomofraphy);VFSS test;Data of surgery on General Anesthesia : ABGA(arterial blood gas anaylyhsis), Catecholamine leve ect.

Secondary

MeasureTime frame
polysomnography;race, age, gender, ingabitation, religionetc, General health conditions;sleep related symptom, cognitive dysfunction, mood symptoms, Difficulties in daily life, Functional performance disorder

Countries

Korea, Republic of

Contacts

Public ContactHyungchae Yang

Chonnam National University Hospital

dr.yang@hanmail.net+82-62-220-6776

Outcome results

None listed

Source: CRIS (via WHO ICTRP) · Data processed: Feb 4, 2026