Effects of arterial CO2 partial pressure on the postoperative cognitive dysfunction

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0004868

Enrollment

400

Registered

2020-04-01

Start date

2020-03-30

Completion date

Unknown

Last updated

2020-04-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Procedure/Surgery : maintain normal, low or high arterial partial pressure of CO2 during the surgery Group 1: maintain normal arterial partial pressure of CO2 which is from 38 to 42 mmHg during the su

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: older patients, 65 years of more, undergoing general anesthesia over one hour

Exclusion criteria

Exclusion criteria: 1. language difficulty of literacy problem 2. history of neurologic or cerebrovascular disease 3. surgery requiring prone position 4. surgery on head and neck 5. patients with decreased cardiac output 6. patients with anemia which hemoglobin is 10g/dL or less 7. patients with preoperative hypoxemia 8. chronic obstructive pulmonary disease 9. patients suspiscious of increased intracranial pressure

Design outcomes

Primary

Measure	Time frame
The incidence of postoperative cognitive dysfunction	—

Secondary

Measure	Time frame
The incidence of postoperative delirium;analgesic requirement and the incidence of postoperative nausea and vomiting	—

Countries

Korea, Republic of

Contacts

Public ContactARam Doo

Chonbuk National University

Outcome results