None listed
Conditions
Interventions
Radiation : All the patients will undergo radiation therapy for bone
metastasis with prescription dose of 30 Gy in 10 fractions. 100% of
prescribed dose volume should encompass the planning target v
Sponsors
Samsung Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients with hepatocellular carcinoma who were scheduled to undergo radiation therapy for bone metastases were included. Patients were included in the study if they were aged older than 18 years, had been diagnosed to have hepatocellular carcinoma either by histological evaluation or clinical imaging, and have been diagnosed to have metastases in thoracic, lumbosacral vertebra, pelvic bone, or proximal femur. The criteria for considering bone metastasis from hepatocellular carcinoma includes newly developed lesions, clear progression of the lesion revealed from the follow-up examinations, or histopathologic confirmation by bone biopsy if available.
Exclusion criteria
Exclusion criteria: Patients with history of another primary malignancy, history of surgery, radiation therapy, or metallic instrumentation in thoracic, lumbosacral spine, pelvic bone, or proximal femur, contraindication to gadolinium-based contrast agents or MRI examinations, female patients who are pregnant or nursing.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Volume transfer constant (Ktrans) | — |
Secondary
| Measure | Time frame |
|---|---|
| constant rate (Kep), fractional volume of extracellular extravascular space (Ve), blood plasma volume (Vp), apparent diffusion coefficient (ADC), tumor volume;Treatment response based on MD Anderson criteria;time to symptom progression, time to local tumor progression, overall survival | — |
Countries
Korea, Republic of
Contacts
Public ContactJi Hyun Lee
Samsung Medical Center
Outcome results
None listed