None listed
Conditions
Interventions
None listed
Sponsors
Soon Chun Hyang University Hospital Seoul
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: adult patients with systemic slerosis(SSc) or mixed connective tissue disease(MCTD) with active digital ulcers, with or without pulmonary arterial hypertension (PAH), in the last 6 months, from the rheumatology department of the 4 institutions All patients fulfilled the 2013 American College of Rheumatology/EULAR classification criteria or the MCTD criteria according to Sharp et al.
Exclusion criteria
Exclusion criteria: Patients were excluded if they had taken phosphodiesterase type 5 (PDE-5) inhibitors or other endothelin receptor antagonists within 1 month and had used prostacyclin analogues within the previous 3 months 4. The concurrent use of aspirin, calcium channel blocker (CCB), angiotensin-converting enzyme inhibitor (ACEi), and angiotensin II receptor blocker (ARB) was acceptable at the same dose as the last 4 weeks before study enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The numbers of healed and new DUs and the largest diameter of DUs were assessed at baseline and at 4, 8, 16, and 24 weeks after treatment with bosentan | — |
Secondary
| Measure | Time frame |
|---|---|
| nailfold capillaroscopy was performed using a light microscope (SZ-PT; Olympus, Tokyo, Japan) with 200x magnification | — |
Countries
Korea, Republic of
Contacts
Public ContactHyeyoung Kim
Soon Chun Hyang University Hospital Seoul
Outcome results
None listed