Comparison of the effects of palonosetron and ramosetron mixed with intravenous patient-controlled analgesia infusion fluid

Comparison of the effects of palonosetron and ramosetron mixed with intravenous patient-controlled analgesia infusion fluid for the prevention of postoperative nausea and vomiting—A prospective randomized controlled study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0004834

Enrollment

114

Registered

2020-03-16

Start date

2015-09-16

Completion date

Unknown

Last updated

2020-03-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : Patients were randomly allocated to three groups. Palonosetron (0.075 mg) was administered intravenously to all patients before anesthetic induction, and a 100-ml IV-PCA infusion, which contain

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1. Female patients aged 20-70 2. patients who underwent gynecologic laparoscopic surgery 3. patients receiving intravenous patient controlled analgesia after surgery

Exclusion criteria

Exclusion criteria: (1) ASA classification 3 or above, (2) history of adverse events and hypersensitivity to serotonin receptor antagonists, (3) refusal to participate in the study, (4) obesity (body mass index over 30 kg/m2), (5) refusal to undergo pain control through IV-PCA, (6) pregnancy and lactation state.

Design outcomes

Primary

Measure	Time frame
postoperative nausea incidence and severity	—

Secondary

Measure	Time frame
postoperative pain severity	—

Countries

Korea, Republic of

Contacts

Public ContactMyoung Jin Ko

Inje University Haeundae Paik Hospital

Outcome results