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Relationship between epidural steroid dose and HPA axis suppression: Double blinded, Randomized controlled trial

Relationship between epidural steroid dose and HPA axis suppression: Double-blinded, Randomized controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CRIS
Registry ID
KCT0004778
Enrollment
34
Registered
2020-02-28
Start date
2017-11-01
Completion date
Unknown
Last updated
2020-03-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Procedure/Surgery : In this study, participants got epidural steroid injection once. One group (TA 40) received triamcinolone acetonide 40mg and the other group (TA 20) received triamcinolone acetonid

Sponsors

The Catholic University of Korea, Yeouido St. Mary's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: participants met the American Society of Anesthesiologists Physical Status 1 or 2 classification; adults aged over 50 years; men and postmenopausal women; patients diagnosed with lumbar HNP or spinal stenosis on the basis of symptoms (pain nature, pain location, neurogenic intermittent claudication, pain aggravating or relieving factors, etc.), signs (straight leg raising test, sensory, motor, deep tendon reflex, etc.), and magnetic resonance imaging (MRI) findings; and patients who were matched for ESI.

Exclusion criteria

Exclusion criteria: patients absolutely contraindicated for ESI (bleeding tendency and infection at the procedure site); patients who had received any glucocorticoids during recent 3 months; patients who could not take glucocorticoids (allergy to steroid agents, pregnancy, all endocrinological diseases); patients with sleep disturbances; patients taking herbal medicine or contraceptives; patients who had experienced severe stress during the preceding month; and patients who had consumed alcohol for 12 hours or food one hour before sampling.

Design outcomes

Primary

MeasureTime frame
salivary cortisol level

Secondary

MeasureTime frame
Extend of reduction (%) of SC concentration after ESI =(SC on D0 - SC on D1) / SC on D0 × 100;ACTH stimulation test;Numerical rating scale (NRS)

Countries

Korea, Republic of

Contacts

Public ContactHo Sik Moon

The Catholic University of Korea, Eunpyeong St. Mary's Hospital

Outcome results

None listed

Source: CRIS (via WHO ICTRP) · Data processed: Feb 4, 2026