None listed
Conditions
Interventions
Drug : Triple regimen : Clarithromycin 500 mg twice a day, omeprazole 20 mg twice a day, amoxicillin 1000 mg twice a day for 10 days
Quadruple regimen: Omeprazole 20 mg twice a day, bismuth 300 mg twi
Sponsors
Seoul National University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Men and women over 18 years of age at the time of initial diagnosis 2. At least one positive serum anti-helicobacter antibody or urease breath test 3. Patients with platelet count 40 × 10^3 / µL or more at initial diagnosis 4. Able to read, understand and voluntarily provide written Informed Consent.
Exclusion criteria
Exclusion criteria: 1. Age under 18 at diagnosis 2. Patients with platelet count less than 40 × 10^3 / µL at first diagnosis 3. Subjects who have previously been treated with Helicobacter pylori eradication 4. Other causes of thrombocytopenia include: autoimmune diseases, hepatitis C virus infection, liver disease, HIV infection, pseudothrombocytopenia 5. Patients taking an immunosuppressant for other disease(s) 6. Patients treated with other solid tumors when idiopathic thrombocytopenia is diagnosed 7. In the case of severe medical or surgical conditions that cannot be followed up in the future 8. Have taken proton pump inhibitors, H2RA, potassium competitive acid blocker (P-CAB), bismuth agents, non-steroidal anti-inflammatory drugs, or antibiotics within the last 4 weeks 9. Patients with history of penicillin allergies or anaphylaxis 10. If the researcher judges that participation in this study is inappropriate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effect of tailored Helicobacter pylori eradication in platelet count recovery | — |
Secondary
| Measure | Time frame |
|---|---|
| Helicobacter pylori eradication rate in ITP patients | — |
Countries
Korea, Republic of
Contacts
Public ContactAyoung Lee
Seoul National University Hospital
Outcome results
None listed