None listed
Conditions
Interventions
Drug : Gliatamine 400mg 2t qd for 12weeks
Sponsors
Seoul National University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients with migraine headaches in need of prophylaxis who meet all of the following criteria may participate in this clinical trial. 1. Whom agrees to participate in the study 2. Adults 19 – 85 years old 3. Those who meet the ICHD-III beta migraine diagnostic criteria and complain of cognitive decline * Those who complain of cognitive decline Are not dementia due to mild cognitive impairment (MCI) and have an MMSE of 22 to 26 or less -Patients with “subjective memory disorder” complain of memory disorder even though normal on cognitive function test and not mild cognitive impairment or dementia 4. Who can read and understand the questionnaire? 5. For women of childbearing age who are taking appropriate contraception or who are negative on a pregnancy test.
Exclusion criteria
Exclusion criteria: 1. Subjects suspected of having drug withdrawal due to headache seizures during baseline or evaluation 2. First-time migraine sufferers at age 50 or older. 3. Subjects with advanced neurological disease 4. Subjects with renal or hepatic insufficiency (patients whose blood creatinine, AST, ALT, and total bilirubin levels are at least 1.5 times the upper limit of normal) 5. Subjects with severe cardiovascular disease 6. Subjects with hypersensitivity to glycatamine 7. Pregnant and lactating women 8. Subjects who participate in other clinical trials under research and development 9. If the researcher judges that participation in this study poses a threat to the well-being of the subject or results in an unreliable evaluation at the end of the study. 10. Subjects with a history of peptic ulcer 11. Subjects with a history of allergies to NSAIDs 12. Subjects who received migraine prophylaxis within the last 4 weeks (including propranolol, sibelium, verapamil, tricyclic antidepressant, valproic acid, topiramate, gabapentin) 13. Subjects with a history of alcohol and drug abuse.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Korean-Mini-Mental State Examination (K-MMSE) | — |
Secondary
| Measure | Time frame |
|---|---|
| MIDAS (Migraine Disability Assessment) | — |
Countries
Korea, Republic of
Contacts
Public ContactWoo-Jin Lee
Seoul National University Hospital
Outcome results
None listed