Reactive Oxygen Species (ROS) Scavenger in Adult Hemorrhagic Stroke Patients

Reactive Oxygen Species (ROS) Scavenger in Adult Hemorrhagic Stroke Patients: The Effect of Perihematomal Edema Reduction and Its Subsequent Clinical Outcome

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0004628

Enrollment

110

Registered

2020-01-16

Start date

2019-10-18

Completion date

Unknown

Last updated

2021-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : Cerebral hemorrhage patients (or their legal representatives) will voluntarily begin ROS removal after signing the research agreement. Two kinds of free radical scavenger (selenium, acetylcyste

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Age =18 years and = 80 years 2. Acute ICH due to hypertensive, cerebral amyloid angiopathy (CAA), arterio-venous malformation (AVM), cavernous malformation (CM) or venous thrombosis 3. Brain tumor bleeding 4. Cerebral infarct 5. Expected ICU stay > 48 hours

Exclusion criteria

Exclusion criteria: 1) Trauma related brain hemorrhage 2) ICH secondary to hematologic malignancy (acute myeloid leukemia, acute lymphocytic leukemia) 3) ICH due to disease like moyamoya, aneurysmal SAH or hemorrhagic cyst rupture like arachnoid cyst 4) ICH due to thrombocytopenia (< 50 000 x10³/uL) or coagulopathy (> 2 INR) 5) Patient taking antiplatelets (aspirin, clopidogrel or cilostazole) or anticoagulation (heparin or low-molecular weight heparin [LMWH], vitamin K antagonist (warfarin) or direct oral anticoagulants [DOAC]) 6) History of cerebrovascular, tumor or any other disease that makes difficult to evaluate the extent of hemorrhage or edema from the current CT 7) Brain death or imminent death (not expected to be in ICU for more than 48 hours) 8) Pregnant patient 9) Liver cirrhosis – Child’s class C liver disease 10) Seizure disorder requiring anticonvulsant medication 11) Post - cardiac arrest with suspected significant anoxic brain injury 12) DNR (do not resuscitate) ordered patients

Design outcomes

Primary

Measure	Time frame
30-day neurologic outcome using mRS	—

Secondary

Measure	Time frame
Duration of intensive care unit admission;Time to reach target sedation level (RASS target: -2 - 0);The length of ICU stay;Length of hospital stay;Perihematomal edema changes;vasospasm	—

Countries

Korea, Republic of

Contacts

Public ContactMoinay Kim

University of Ulsan

Outcome results