None listed
Conditions
Interventions
None listed
Sponsors
Inje University Haeundae Paik Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: In case that the below three conditions are fulfilled 1) Age : 19 years old or more 2) Chronic alcohol intake (WHO harmful drinking criteria): Male >60 g/day, Female > 40 g/day 3) Abnormal liver function a. Total bilirubin = 5 mg/dL b. AST 40~500 U/L c. ALT 2 4) Modified Maddrey discriminant function (mMDF) score = 32 *mMDF = 4.6× [PTpatient – PTcontrol] (sec) + total bilirubin (mg/dL)
Exclusion criteria
Exclusion criteria: Any one of the below conditions 1) Persistent jaundice over 3 months 2) Recent abstinence period over 2 months 3) Acute or chronic viral hepatitis (HAV, HBV, HCV) 4) Autoimmune hepatitis 5) Neoplasm including hepatocellualr carcinoma 6) Toxic hepatitis or drug-induced liver injury 7) Acute pancreatitis 8) Gastrointestinal bleeding 9) Acute cholecystitis or cholangitis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diagnostic accuracy of procalcitonin for bacterial infection in severe acloholic hepatitis (c-statistics) | — |
Secondary
| Measure | Time frame |
|---|---|
| Diagnostic accuracy of c-reactive protein for bacterial infection in severe acloholic hepatitis (c-statistics);Diagnostic accuracy of procalcitonin and c-reactive protein for SIRS in severe acloholic hepatitis (c-statistics);Diagnostic accuracy of procalcitonin and c-reactive protein for sepsis in severe acloholic hepatitis (c-statistics) | — |
Countries
Korea, Republic of
Contacts
Public ContactNae-Yun Heo
Inje University Haeundae Paik Hospital
Outcome results
None listed