None listed
Conditions
Interventions
Others : The non-intervention group will perform the regular walking exercise and will implement the structured multi-domain exercise intervention program in the intervention group. Both groups are 20
Sponsors
Ajou University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. One or more of the following dementia risk factors: 1) Hypertension on medication 2) Diabetes mellitus on oral hypoglycemic agent or insulin 3) Dyslipidemia on medication 4) Obesity: BMI 25kg/m2 and above 5) Smoking: patients who have smoked at least 100 cigarettes in their lifetime and smoked more than 1 cigarette in the last month 6) Excessive drinking: more than 170 grams of alcohol per week 7) An educational background of less than 9 years 8) Aerobic exercise with moderate strength (3~6 METS) less than 150 minutes per week (more than 30 minutes, more than 5 days a weak) or high-intensity aerobic exercise (>6METS) less than 60 minutes per week (20 minutes or more, 3 days or more per week) 9) Insufficient strength exercise; do not perform 8 to 10 muscle group exercises for 10 to 15 repetitions per every exercise session for 2 days or more per week 2. No significant daily life dysfunction: KIADL 0.42 or below 3. The participant should not be dementia in the judgement of clinicians. 4. Literacy 5. Written consent to participate in the research
Exclusion criteria
Exclusion criteria: 1. Mental illness such as major depression disorder 2. Dementia 3. Other neurodegenerative diseases such as Parkinson's disease 4. MMSE z-score -1.5 or less 5. Malignant tumors within 5 years of not being cured 6. Revascularization or stent insertion within 1 year 7. Severe or unstable symptomatic cardiovascular disease 8. Any other evidence of serious or unstable physical condition (acute or severe asthma, active gastrointestinal ulcer, severe liver disease or kidney disease enough to receive dialysis), patients with other medical conditions that may interfere with the completion of the clinical trial 9. Severe vision loss, severe hearing loss, or communication impairment beyond which intervention and validation cannot be performed 10. Illiteracy 11. In case it is deemed difficult to participate in the research in cooperation with the researchers' judgment to the end 12. In case of difficulty in safely participating in arbitration programs in the judgment of the researchers 13. Participation in other intervention studies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| physical activity (muscle strength, balance, flexibility, cardiopulmonary endurance, cooperation);Neuropsychological test for cognitive evaluation;brain imaging (brain MRI for evaluating cortical thickness and activated brain area);Electroencephalogram;Blood biomarker (BDNF, anandamide, 2-arachidonoylglycerol) | — |
Secondary
| Measure | Time frame |
|---|---|
| Emotional state (depression, anger proneness) | — |
Countries
Korea, Republic of
Contacts
Public ContactKyunghwa Sun
Ajou University Hospital
Outcome results
None listed