None listed
Conditions
Interventions
Drug : Botulinum toxin (type A) is intraoperatively administered during partial parotidectomy to prevent sialocele/salivary fistula. Botulinum toxin (5 unit/ml) was injected at the 5 points indicated.
Sponsors
Pusan National University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The patients who supposed to undergo partial parotidectomy for therapeutic purpose.
Exclusion criteria
Exclusion criteria: The exclusion criteria were as follows: patients who have (1) the history of botulinum toxin administration in 3 months (2) the experience of hypersensitivity or allergic reaction for botulinum toxin (3) the history of the operation for high-risk cancer (4) coagulopathies (5) the possibility of pregnancy or are breastfeeding (6) the history of spastic cerebral palsy, peripheral motor neuropathies (Amyotrophic lateral sclerosis and other motor neuron diseases) (7) the history of neuromuscular junction diseases (myasthenia gravis) and other neuromuscular diseases (8) severe respiratory failure (9) systemic lupus erythematosus (10) the needs of aminoglycoside, spectinomycin, polymyxin, tetracycline and lincomycin.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of facial nerve paralysis for safety;The incidence of postoperative sialocele and salivary fistula for the efficacy. | — |
Secondary
| Measure | Time frame |
|---|---|
| Drainage volume during admission;Minor complication after discharge (hemorrhage/hematoma, infection, wound dehiscence, re-admission, dry mouth) | — |
Countries
Korea, Republic of
Contacts
Public ContactWonjae Cha
Pusan National University Hospital
Outcome results
None listed