None listed
Conditions
Interventions
Dietary Supplement : - Test group: Extraction of Ligularia stenocephala and wheat sprout (ELW) 300mg capsule (extracted with 50%
alcohol), 1 capsule for daily oral intake for 4 weeks
_ Control group: Placebo dextrin 300mg capsule with same shape and color with ELW. 1 capsule for daily oral intake for 4 weeks
Subjects were rando
Sponsors
Yonsei University Health System, Dental Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Male or female whose age is in 18~80 years old 2) Subjects who have more than 18 natural teeth 3) Subjects who have sites with probing depth more than 3mm 4) Subjects who have at least two teeth with bleeding on probing in a sextant 5) Subjects who are diagnosed as gingivitis or chronic generalized incipient to moderate periodontitis
Exclusion criteria
Exclusion criteria: 1) Subjects who did not sign on a written consent form. 2) Subjects who are pregnant or lactating 3) Subjects who have uncontrolled systemic diseases like severe hypertension and diabetes 4) Subjects who did not enroll in other clinical studies in recent 3 months 5) Subjects who are intaking antiplatelet or anticoagulant or who have hemorrhagic disease 6) Subjects who had cancer in past 5 years. 7) Subjects who had antibiotic therapy in a recent month 8) Subjects who had periodontal treatment in recent six month, except scaling 9) Subjects who have pathologic appearance (e.g: leukoplakia, lichen planus) 10) Subjects who are decide not to be appropriate in clinician's decision 11) Subjects who had allergy in ingredients for medication 12) Subjects who smokes more than 10 cigarrettes / day
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bleeding on probing, Clinical attachment loss | — |
Secondary
| Measure | Time frame |
|---|---|
| Levels of biomarkers in saliva and gingival crevicular fluid;Blood test data | — |
Countries
Korea, Republic of
Contacts
Public ContactInpyo Hong
Yonsei University Health System, Dental Hospital
Outcome results
None listed