The Effect of Early Correction of Serum Calcium and Magnesium in Acute Hemorrhagic Stroke Patients

Prognostic Scoring System in Brain Hemorrhage Patients: the clinical value of serum magnesium and calcium

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CRIS

Registry ID

KCT0004427

Enrollment

102

Registered

2019-11-05

Start date

2019-10-30

Completion date

Unknown

Last updated

2020-06-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : Patients will be assigned to two groups Strictly Managed Group vs. Liberally Managed Group 1. Strictly managed Group a. Early and upper normal correction of serum Ca, Mg (within 48 hours of v

9 mg/dL (8.6-10.2 mg/dL) Pseudohypocalcemia -Albumin correction (&gt

3.5 mg/dL) ii. Serum Mg &gt

2 mg/dL (1.8-3.0 mg/dL) 2. Liberally Managed Group *Correction & Maintain serum Ca. and Mg. level till ICU stay or maximum of 7 days

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Age =18 years and = 80 years 2. Acute hemorrhagic stroke patients: traumatic intracerebral or intraventricular hemorrhage (ICH or IVH), spontaneous ICH or IVH, vascular structure related ICH or IVH (AVM, CM), subdural or epidural hematoma (SDH or EDH), tumor bleeding 3. Glasgow Coma Score (GCS): 5-15 4. Operation or non-operation cases 5. Expected ICU stay > 48 hours

Exclusion criteria

Exclusion criteria: 6. Disease that hypercalcemia may be harmful Subarachnoid hemorrhage (SAH) d/t aneurysm rupture or trauma Moyamoya disease (MMD) Medical disease: AKI, coronary diseases (myocardial infarction), gout, hyperparathyroidism 7. On antiplatelets or anticoagulation agents (aspirin, clopidogrel, cilostazol, heparin, warfarin ?vitamin K antagonist?, DOAC ?Direct Oral Anticoagulants?) 8. Hematologic disorder or thrombocytopenia ( < 50, 000/µL) 9. Post-anoxic coma; status epilepticus without underlying brain injury; central nervous system (CNS) infections (community-acquired; hospital-acquired; ventriculitis; post-operative) 10. Brain death or imminent death (within 24 hours) 11. Pregnancy or nephrotic syndrome diagnosed patient 12. DNR (do not resuscitate) orders

Design outcomes

Primary

Measure	Time frame
The extent of brain hemorrhage	—

Secondary

Measure	Time frame
neurologic outcome (modifed Rankin Score, Glasgow Outcome Scale);Days of intensive care unit admission;Days of hospital admission;Tracheostomy	—

Countries

Korea, Republic of

Contacts

Public ContactMoinay Kim

University of Ulsan

Outcome results