Effect of anesthetic method on inflammatory response in Parkinson' disease

Effect of inhalational anesthetics and total intravenous anesthesia on inflammatory cytokine after surgery in patients with Parkinson’s disease

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CRIS

Registry ID

KCT0004410

Enrollment

Registered

2019-10-31

Start date

2018-06-10

Completion date

Unknown

Last updated

2019-11-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : Patients in the inhalation anesthesia group induce anesthesia by tracheal intubation 1-2 minutes after propofol 1-2 mg / kg and rocuronium 0.6-1 mg / kg IV administration. Thereafter, anesthesi

Sevoflurane, 0.01-0.2 kg / kg / min remifentanil, and O 2 / air (FiO 2 0.4). In total intravenous anesthesia(TIVA) group, propofol 3-6 µg / ml, remifentanil 2-6 ng / ml, rocuronium 0.6-1 mg / kg using

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with Parkinson's disease aged 40-75 years who underwent cerebral stimulator implantation to control symptoms under general anesthesia

Exclusion criteria

Exclusion criteria: patients without signing consent, patients with myocardial infarction or coronary artery disease aside from diabetes and hypertension heart disease, patients with lung disease such as asthma or chronic obstructive pulmonary disease (COPD), patients with AST / ALT greater than normal, patient with a medical history or a history of hypersensitivity to inhalation anesthetics or propofol

Design outcomes

Primary

Measure	Time frame
perioperative serum IL-17 level	—

Secondary

Measure	Time frame
perioperative serum IL-1?, TNF-?	—

Countries

Korea, Republic of

Contacts

Public ContactJin Joo

The Catholic University of Korea, Seoul St. Mary's Hospital

jiyo1004@hanmail.net+82-2-2258-6162

Outcome results