None listed
Conditions
Interventions
None listed
Sponsors
National Cancer Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: - Never treated, newly diagnosed classical Hodgkin lymphoma patient by pathologic examination - age 18 and older - ECOG 0-2 - At least one measurable lesion (2cm or more on conventional CT or 1cm or more on spiral CT) - At least one identifiable uptake of nodes or extranodal lesion on FDG PET-CT - Adequate renal function (serum creatinine =2.5mg/dL, creatinine clearance = 50mL/min) - Adequate liver function (AST and ALT = 3 times of upper normal limit, bilirubin = 1.5 times of upper normal limit, alkaline phosphatase = 5 times of upper normal limit) - Adequate bone marrow function (ANC = 1,500/uL, platelet =75,000/uL, hemoglobin = 9.0g/dL) - Adequate cardiopulmonary function - Voluntary achieved informed consent approved by institutional review board
Exclusion criteria
Exclusion criteria: - Not correspond to inclusion criteria - Malignant tumor within 5 years of enrollment except skin basal cell carcinoma and cervix carcinoma in situ. - Clinically significant medical status (uncontrolled cardiac disease, history of myocardial infarction within 6 months of enrollment, uncontrolled pulmonary disease, significant neurological or psychological disease including dementia and epilepsy, uncontrolled active infection) - Pregnancy or breastfeeding, childbearing-age female without adequate contraception - Confirmed allergic response to drugs of present study - Not consent to present study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall survival | — |
Secondary
| Measure | Time frame |
|---|---|
| event free survival, progression free survival, overall response rate to initial therapy, overall response rate to induction therapy, clinical characteristics (prognosis related factors), toxicity profile, quality of life profile, treatment-related adverse event | — |
Countries
Korea, Republic of
Contacts
Public ContactEunyoung Lee
National Cancer Center
Outcome results
None listed