Efficacy and safety study of Topical tranexamic acid to decrease postoperative blood loss in total knee arthroplasty

Efficacy and safety of Topical tranexamic acid to decrease postoperative blood loss in total knee arthroplasty -Prospective Randomized Controlled Study

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CRIS

Registry ID

KCT0004298

Enrollment

325

Registered

2019-10-02

Start date

2016-01-28

Completion date

Unknown

Last updated

2019-10-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : A total of 325 patients who were scheduled to undergo TKA are recruited in a prospective randomized double-blinded and placebo-controlled comparative study. The patients are randomly assigned t

group 1, 0.5 g TXA

group 2, 1.0 g TXA

group 3, 2.0 g TXA

and group 4, 3.0 g TXA

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who were suffering from knee osteoarthritis and were scheduled to undergo total knee arthroplasty

Exclusion criteria

Exclusion criteria: acquired disturbances of color vision, preoperative anemia (a hemoglobin level of <11 g/dL in females and <12 g/dL in males), coagulopathy (as identified by a preoperative platelet count of <150,000/mm3, international normalized ratio of >1.4, or prolonged partial thromboplastin time [>1.4 times normal]), history of arterial or venous thromboembolic disease (such as a cerebrovascular accident, deep-vein thrombosis, or pulmonary embolus),

Design outcomes

Primary

Measure	Time frame
decrease in postoperative hemoglobin level	—

Secondary

Measure	Time frame
blood loss calculated using Good's method,;drainage volume;frequency of transfusion	—

Countries

Korea, Republic of

Contacts

Public ContactLee Chul

Seoul National University Hospital

Outcome results