None listed
Conditions
Interventions
None listed
Sponsors
Ewha Womans University Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: ? Adult patients whose age is over 20 years of age and whose jaw growth has been completed ? If you have or have been given a medication that can cause jaw necrosis:IV Bisphosphonate, Denosumab, Angiogenesis inhibitor, etc.Oral use for more than 2 years ? Patients who are scheduled to perform an action that increases the risk of jaw necrosis or have a risk factor (Oral surgery such as extraction, implant, and denture that does not fit well, periodontitis, etc.) ? Patients who agreed to participate in the clinical trial and signed the patient consent form
Exclusion criteria
Exclusion criteria: ? If there is a history of radiation therapy in the head and neck, including jaw, or a malignant tumor of the jaw area ? Patients taking oral bisphosphonate for 2 years or less ? If the examiner determines that participation in the clinical trial is inadeqyate becayse it may affect other ethical or clinical trial results
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood tests: Calcitonin, C-telopeptide of collagen type 1 (CTX), N-telopeptide (NTX), PYRILINKS-D(Deoxypyridinoline), Osteocalcin, Bone sepcific Alkaline phosphatase (ALP), Parathyroid Hormone (PTH) Intact, 1,25-(OH)2 (1.25 dihydroxy Vitamin D), total, Total calcium | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical characteristic / Demographic evaluation;Radiation examination | — |
Countries
Korea, Republic of
Contacts
Public ContactSeon Kim
Ewha Womans University
Outcome results
None listed