None listed
Conditions
Interventions
Dietary Supplement : Test supplement1 : Phellinus linteus extract (1000 mg/day)
Test supplement2 : Phellinus linteus extract (1500 mg/day)
Placebo supplement: Placebo
8-week, 6 capsules/day, twice
Sponsors
Cheonan Korean Medicine Hospital of Daejeon University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) 40-75 year old male and female with knee pain for 6 months or more (2) A Kellgren-Lawrence grading scale of 1 grade or 2 grade on both knee X-ray examinations (3) If subject is taking arthritic medications, subject has not changed his/her medication within the past a month (4) Subject who agrees to participate in the study and signs the informed consent form
Exclusion criteria
Exclusion criteria: (1) A patient who are currently being treated for clinically significant acute or chronic cardiocerebrovascular system, immune system, respiratory system, hepatobiliary system, kidney and urinary system, nervous system, musculoskeletal disorders, mental, infectious and blood and tumor diseases (2) A person who is arthritis due to a specific factor other than degenerative (3) Those who have a history of fractures of the lower limb within the last 3 months (4) Those who have creatinine blood level that is more than twice the normal upper limit of the organ (5) A patient who received intra-articular injection with hyaluronic acid or steroids within 3 months of the study (6) Those who have AST or ALT blood level that is 3 times higher than normal upper limit (7) Those who have uncontrolled hypertension(160/100mmHg ??) (8) Patients taking medication for psychiatric disorders (9) Those who have been taking herbal medicine for the last two weeks (10) Those who have received other research drugs within the last 4 weeks (11) Persons who must continue to take drugs that they think may affect the results of clinical trial (12) Those who have a history of gastrointestinal resection (13) Those who have had artificial joint surgery (14) Those who are pregnant or breastfeeding (15) Alcoholic or drinking more than 4 times/week (16) Persons with hypersensitivity to the research food or its components (17) Any other researcher deemed inappropriate for this test
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| K-WOMAC(Korean Western ontario and McMaster Universities Questionnaire) (pain, rigidity, physical function) | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS(Visual Analog Scale);EQ-5D(EuroQol-5D);Inflammation markers;Adverse event | — |
Countries
Korea, Republic of
Contacts
Public ContactHwa-yeon Ryu
Cheonan Korean Medicine Hospital of Daejeon University
Outcome results
None listed