Stress and immune response:According to Anesthesia Types undergoing Urological Surgery in elderly patients.

Stress and immune response: A comparison of General versus Spinal Anesthesia in Transurethral prostate/bladder resection in elderly patients.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0004256

Enrollment

Registered

2019-08-28

Start date

2017-08-08

Completion date

Unknown

Last updated

2019-10-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Procedure/Surgery : We compared the sympathetic nervous system, immunologic, and glucose metabolic responses between general and spinal anesthesia in older adults who underwent urological surgery. In

nitrous oxide in oxygen with 6&#37

desflurane was used for maintenance. The flow of anaesthetic gas mixture was 4 L/min during the surgery. At the end of surgery, residual muscle relaxation was antagonised using glycopyrrolate with pyr

hyperbaric bupivacaine into the subarachnoid space, and patients were maintained in the supine position for 3 to 5 min. Peripheral venous blood was collected before anesthesia (T0) and at 8 hours (T1)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients aged 65 years and above with an American Society of Anesthesiologists physical status classification of I–II who were scheduled to undergo elective transurethral resection of the prostate/bladder

Exclusion criteria

Exclusion criteria: Congestive heart failure (ejection fraction <35%); thyroid, pituitary, adrenal, kidney, or liver disease; glucocorticoid medication; hormone replacement therapy; malignancies; signs of acute infection or inflammation; obesity; and other conditions for which spinal anesthesia is contraindicated.

Design outcomes

Primary

Measure	Time frame
Plasma concentrations of epinephrine, norepinephrine, cortisol, CD4+ T cells	—

Secondary

Measure	Time frame
Plasma concentrations of glucose, insulin, C-reactive protein	—

Countries

Korea, Republic of

Contacts

Public ContactHye Young Kim

Kunkuk University Chungju Hospital

hae1127@hanmail.net+82-43-840-8320

Outcome results