None listed
Conditions
Interventions
Dietary Supplement : Treatment group: 1 tablet, once a day (250 mg as Chrysanthemum zawadskii Herbich var. latilobum (Maxim.) Kitamura extract)
Control group: 1 tablet, once a day (0 mg as Chrysanthem
Sponsors
Inje University Seoul Paik Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Adult male and female between 40 years and 75 years Patients diagnosed more than 30mm in VAS (Visual analogue scale) Patients diagnosed grade I, II with kellgren & Lawrence grading scale in X-ray Those who agree to the written consent of the applicant and who can cooperate with the necessary visits and related tests and surveys for the study process
Exclusion criteria
Exclusion criteria: (1) Subjects diagnosed with arthritis by specific factors othre than degenerative arthritis (2) Joint spacing less than 2mm (3) Subjects who are judged to have severe arthritis with bony spur, irregular articular surface and osteocystoma etc (4) Subjects with clinically significant cardiovascilar, immune, infectious and neoplastic diseases (5) Patients undergoing gastritis and gastric ulcers (6) Subjects with resistant hypertension (Upper than 160/100mmHg, After 10 minutes rest) (7) Subjects with resistant diabetes (Fasting glucose levels upper than 180mg/dl) (8) TSH lower than 0.1µIU/ml or upper than 10 µIU/ml (9) AST(GOT) and ALT(GPT) is at least 3 timesthe normal range (10) Creatinine is at least twice the normal range (11) Pregnant or nursing women (12) Subjects who is on a diet Health Functional Foods and medicine to improve joint/cartilage health (13) Subjects who are treated with mental disorders such as depression and schizophrenia. (14) Oriental medicine treatment of acupuncture, moxibustion, cupping therapy, herbal medicine, etc. within 2 month prior to the study (15) Participation in anothrt clinical trial within 2 month prior to the study (16) Hypersensitivity or allergy to the test materials (17) Participation who are judged to be unable to comply with the requirements of the test
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total score of K-WOMAC (The western ontario and McMaster university osteoarthritis index) | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS (Visual analogue scale) and KSF-36 (Korean-short form health survey 36) | — |
Countries
Korea, Republic of
Contacts
Public ContactYunyoung KIM
Inje University Seoul Paik Hospital
Outcome results
None listed