None listed
Conditions
Interventions
None listed
Sponsors
Seoul National University Hospital
Seoul National University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Cognitively impaired amyloid-PET positive Common criteria -age range between 55-90 -positive deposition on the amyloid-PET scans -have reliable informant Sub-group criteira: 1)AD -linical Dementia Raging = 0.5 or 1 -meets DSM-IV criteria for dementia -meets NIA-AA 2011 criteria for probable dementia 2)Mild Cognitive Impairment (MCI) due to AD -CDR = 0.5 -Does not meet DSM-IV criteria for dementia -Meets NIA-AA 2011 criteria for MCI 2. Preclinical AD with amyloid-PET positive Criteria -age range between 55-90 -positive deposition on the amyloid-PET scans -have reliable informant -CDR = 0 3. Cognitively normal with amyloid-PET negative Criteria -negative for deposition on the amyloid-PET scans -have reliable informant -CDR = 0 Sub-group criteira: 1)Cognitively normal middle-aged group -age range between 55-90 2)Cognitively normal young group -age range between 20-54 4. Cognitively impaired due to non-AD pathology with amyloid-PET negative (Dementia, MCI) Criteria -age range between 55-90 -negative for deposition on the amyloid-PET scans -have reliable informant Sub-group criteria: 1)Dementia due to non-AD pathology -CDR = 0.5 or 1 -Meets DSM-IV criteria for dementia 2)MCI due to non-AD pathology -CDR = 0.5 -Does not meet DSM-IV criteria for dementia -Meets NIA-AA 2011 criteria for MCI
Exclusion criteria
Exclusion criteria: Exclusion criteria for the above groups are as follows: -Presence of major psychiatric illness (e.g., schizophrenia, bipolar disorder, major depressive disorder, alcohol/substance abuse or dependence, delirium) -Significant neurological or medical condition or comorbidities that could affect mental functioning -Contraindications for MRI scan (e.g. pacemaker, claustrophobia) -Illiteracy or serious hearing and/or vision difficulties that prevents completion of neuropsychological assessments -Taking an investigational drug -Current pregnancy, possibly pregnant or breastfeeding -If there is a history of kidney disease or a decrease in renal function (eGFR<60mL/min/1.73m2) at the time of injection of the MR contrast agent. -History of allergic reaction to the MR contrast agent or other medications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brain regional BBB permeability index (Ki, Ktrans) on the high resolution DCE-MRI | — |
Countries
Korea, Republic of
Contacts
Public ContactDong Young Lee
Seoul National University
Outcome results
None listed