None listed
Conditions
Interventions
None listed
Sponsors
Sangji University Oriental Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Adults over 19 years 2) Those who satisfy the follwoing three conditions of 'Modified 1994 research case definition criteria for chronic fatigue syndrome worksheet' ? Clinically evaluated, unexplained, persistent or relapsing chronic fatigue that is of new or definite onset ? The concurrent occurence of four or more of the following symptoms, all of which must have persisted or recurred during 6 or more consecutive months of illness and must not have predated the fatigue ? Exclusion of other clinical causes that may explain fatigue in health screening after the onset
Exclusion criteria
Exclusion criteria: (1) Those who can not open their mouths due to jaw joint disorders (2) Glossities, Anatomical abnormality on the tongue, or intraoral bleeding disorders (3) Smokers (4) Myocardial infarction, Unstable ngina pectoris, Stroke, Cerebral ischemic attack, heart failure, incontrolled arrhythmia, and previous coronary revascularization (5) Severe metabolic disease / Cardiovascular, cerebrovascular disease / Any other diseases or disorders that may affect physical and mental fatigue/ systemic infectious diease requiring treatment (6) Current taking medication or vitamins (7) AST, ALT, or serum bilirubin >UNL X 2.5 times, or drug-induced / alcoholic hepatitis, liver cirrhosis, fatty liver requiring treatment (8) Positive HBsAg, HCB-Ab, HIV test (9) Serum creatinine >UNL X 2 times, or chronic renal failure or any other renal diseases requiring dialysis (10) Uncontrolled diabetes (HbA1c > 9%) (11) Uncontrolled hypertension (SBP >180mmHg or DBP >110 mmHg) or edema (12) History of malignant tumors within the past 5 years (13) Tuberculosis, Multiple sclerosis, hypothyroidism, uncontrolled asthma (14) Bipolar affective disorders, schizophrenia, dementia, delusional disorder (15) History of Anorexia or bulimia or suspected anorexia/bulimia (16) BMI greater that 45 kg/m2 (17) Orthodontic prostheses in the mouoth (18) Pregnant, lactating, or fertile women, or positive urine pregnancy test results (19) Participants in any other clinical studies within one month of screening (20) Anyone who is deemed unsuitable for ohter clinically significnat medical or psychiatric findings
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Distribution of coated tongue | — |
Secondary
| Measure | Time frame |
|---|---|
| Weight of coated tongue;Color of dorsal part of tongue (Total area / Area with no coated tongue / Area with coated tongue);Fatigue Severity Scale (FSS);Pittsburgh Sleep Quality Index (PSQI) | — |
Countries
Korea, Republic of
Contacts
Public ContactUi Min Jung
Sangji University Oriental Medical Center
Outcome results
None listed