Comparison between two methods of intravenous titration of morphine for rapid control of severe cancer pain: patient-controlled analgesia using optimizing B.I. mode vs. conventional method

Comparison between two methods of intravenous titration of morphine for rapid control of severe cancer pain: patient-controlled analgesia using optimizing B.I. mode of “PAINSTOP” equipment vs. conventional method

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0004008

Enrollment

Registered

2019-05-29

Start date

2020-03-27

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Medical Device : Patients with conventional pain control method (Control arm) will get 24 hour of continuous intravenous infusion of morphine with additional bolus morphine for breakthrough pain of NR

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Cancer patient, age of 19 or more 2. Life expectancy more than a month 3. Admitted patient 4. Failure of appropriate pain control by oral or transdermal opioids 5. Average daily pain score (numerical rating scale; NRS) 4 or more of previous 3 days 6. Painkiller equivalent to intravenous morphine of 10-200mg/day for previous 24 hours 7. Voluntarily participated patients with informed consent

Exclusion criteria

Exclusion criteria: 1. Contraindication for studied drug(morphine sulfate) intravenous infusion (had hypersensitivity, persistent asthma attack, severe respiratory distress to opioid drug) 2. Patients with uncontrolled psychiatric disease 3. Patients who can't read the informed consent form(Illiterates, foreigners) 4. Patients with cognitive impairment evaluated by Korean Mini-Mental State Examination(K-MMSE)

Design outcomes

Primary

Measure	Time frame
Difference of average times of patient having breakthrough pain(NRS of more 4 or more) between two groups	—

Secondary

Measure	Time frame
Analgesic effect;Psychological effect;safety	—

Countries

Korea, Republic of

Contacts

Public ContactHye Jin Choi

Yonsei University Health System, Severance Hospital

choihj@yuhs.ac+82-2-2228-8133

Outcome results