None listed
Conditions
Interventions
Drug : Intensive treatment group vs. Standard treatment group
SBP target will be different between two groups (130 mmHg in intensive group vs. 140 mmHd in standard group)
Hypertension medication will
Sponsors
Chungbuk National University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) aged above 65 years 2) Hypertension patients - taking antihypertensive medications - newly diagnosed with hypertension (systolic pressure between 140 and 180 mmHg) 3) possible self-care (Activities of Daily Living (ADL) score above 100) 4) subjects with informed consent
Exclusion criteria
Exclusion criteria: 1) patients who did not agree to study 2) past medical history of secondary hypertension or suspicious secondary hypertension 3) resistant hypertension 4) orthostatic hypotensioin at screening 5) uncontrolled diabetes mellitus at screening (HbA1c above 10%) 6) end stage renal disease (on hemodialysis or eGFR less than 15 mL/min/1.73m2) 7) underwent acute coronary syndrome, cardiac surgery, or urgent percutaneous coronary intervention within recent 3 months 8) systolic heart failure with ejection fraction less than 40% 9) hypertrophic obstructive cardiomyopathy, aortic stenosis, moderate to severe valve disease, congenital heart disease 10) diagnosed with acute cerebral infarction within recent 3 months 11) diagnosed with moderate to severe retinopathy (retinal hemorrhage, visual impairment, microaneurysm) within recent 6 months 12) wasting disease, autoimmune disease, connective tissue disease 13) clinically significant liver disease or level of AST/ALT greater than 3 times upper normal range 14) uncontrolled thyroid dysfunction 15) enrolled other clinical trials within 4 months or plan to participant other clinical trials during our study 16) other reasons limiting participant or progress of study according to investigators' judgement
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| overall cardiovascular mortality | — |
Secondary
| Measure | Time frame |
|---|---|
| cardiovascular mortality;quality of life;cognitive function assessment;frailty assessment | — |
Countries
Korea, Republic of
Contacts
Public ContactJu-Hee Lee
Chungbuk National University Hospital
Outcome results
None listed