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Changes in left ventricular afterload after aortic valve replacement in severe aortic stenosis patients

Changes in left ventricular afterload after aortic valve replacement in severe aortic stenosis patients with preserved left ventricular ejection fraction and high pressure gradient of transaortic blood flow

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CRIS
Registry ID
KCT0003639
Enrollment
29
Registered
2019-03-19
Start date
2019-03-18
Completion date
Unknown
Last updated
2019-03-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

None listed

Sponsors

Asan Medical Center
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: -severe aortic stenosis patients (aortic valve area < 1.0 cm2) who undergo elective aortic valve replacement -left ventricular ejection fraction =50% on preoperative transthoracic echocardiography -mean transaortic pressure gradient = 40 mmHg on preoperative transthoracic echocardiography

Exclusion criteria

Exclusion criteria: -patietns who show preoeprative atrial fibrillation or atrial flutter -patients with inotropic drug or mechanical assist device to stabilize the hemodynamics -patients with moderate or severe aortic regurgitation combined with aortic stenosis -patients with moderate or severe disease in other valve -patietns who undergo emergency surgery

Design outcomes

Primary

MeasureTime frame
arterial elastance—

Secondary

MeasureTime frame
systemic vascular resistance;arterial compliance;valvuloarterial impedance—

Countries

Korea, Republic of

Contacts

Public ContactJi-Hyun Chin

Asan Medical Center

cjh@amc.seoul.kr+82-2-3010-5632

Outcome results

None listed

Source: CRIS (via WHO ICTRP) · Data processed: Feb 4, 2026