None listed
Conditions
Interventions
Dietary Supplement : Subjects are randomly assigned and divided into test groups 1, test groups 2, and control groups.
In test group 1, 300mg of hydrangea leaf extract, which is a test food, is taken
Sponsors
COSMAX BIO
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Men and women aged 35 and over 60 years old (2) A person who is rated 3 grade with a diameter of wrinkle in thr eyes or higher in a visual evaluation (3) Measure the moisture content of both cheeks using corneometer® and measure the average score of 49 points or less. (4) A person who agrees to participate in this clinical trial test before the commencement of the clinical trial and has signed the written consent
Exclusion criteria
Exclusion criteria: (1) A person who suffers or is currently undergoing treatment from skin diseases such as atopic dermatitis and psoriasis. (2) Any person who is sensitive or allergic to food for testing (3) A person who experiences skin problems such as spots, pimples, iris, and capillary expansion at the test site (4) A person who received treatment on the face (skin stripping, chemical peeling, other skin care, etc.) within one month of the beginning of a test or treatment on the face of botox, filler, etc. within six months (5) A person who uses a steroid-containing skin ophthalmoid on the face or takes an systemic retinoid/steroid within three months of testing (6) A person who used functional cosmetics (retinoid agents, retinol, AHA) or highly moisturized cosmetics to improve wrinkles within two weeks from the start of a test (7) A person who has taken diet pills (absorbent and antidepressants, appetite suppressants, etc.), birth control pills or hormone medications, and diuretic medications within one month of testing (8) A person who has taken antioxidants, hyaluronic acid, health function foods containing collagen, drug medicines or health function foods containing evening primrose seed oil, vitamin A, vitamin C, vitamin E within two weeks of testing (9) AST (GOT) or ALT (GPT) greater than 120 IU/L or ?-GTP greater than 180 IU/L. (10) A person whose creatine is 2.4 mg/dL or higher (11) not more than 0.1 µIU/ml of TSH or more than 10 µIU/ml (12) High blood pressure unadjusted (160/100mmHg or higher, based on measurement after 10 minutes of stabilization) (13) Diabetic patients with no blood sugar adjusted (greater than 180 mg/dl per fasting glucose) (14) Mental patients with schizophrenia, depression, and drug addiction (15) A person who is pregnant, nursing or planning to become pregnant within three months (16) A person inpatients, medications, and rehabilitating for alcohol use, induced disability, heart disease, and central neurological disorder through a medical history survey (17) Smokers or persons less than one year after quitting smoking. (18) A person who participated in another clinical trial within one month of the start of the test or who is planning to participate during the test period; (19) A person who participated in the same clinical trial within six months of the beginning of the test or who is planning to participate during the test period; (20) A person who is deemed inappropriate by the tester for this test
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Skin wrinkling;Skin moisture | — |
Secondary
| Measure | Time frame |
|---|---|
| Loss of skin moisture;Skin elasticity;Skin texture;Roughness of skin;Improvement of the tester;Improvement of the test subjects;Abnormal events;clinical pathological examination(hematological/hemochemical examination, urinalysis);Vital signs;physical measurement(body weight) | — |
Countries
Korea, Republic of
Contacts
Public ContactLee Hoon
Global Medical Research Center
Outcome results
None listed