None listed
Conditions
Interventions
Drug : Patients, who treated hypertensive or durg-naïve hypertensive, undergo run-in period during 4weeks with 20mg dose of olmesartan monotherapy. In order to confirm the patients compliance of the a
Sponsors
Yonsei University, Wonju Severance Christian Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients aged over 20 years 2) No previous history of cardiovascular disease or Treated hypertensive or drug-naïve hypertensive patients 3) Mean SBP = 140 and/or DBP =90 mmHg
Exclusion criteria
Exclusion criteria: 1) Poor compliance of ambulatory monitoring device during run-in period 2) pregnant women, possible candidate for pregnancy or breast feeding females 3) known or suspected secondary hypertension 4) mean seated SBP = 180mmHg and/or mean seated DBP = 120mmHg at any visit 5) any clinically significant hepatic impairment 6) severe renal impairment (serum creatinine >2.0mg/dl) 7) bilateral renal artery stenosis or renal artery stenosis in a solitary kidney or post-renal transplant 8) clinically relevant hyperkalemia 9) uncorrected volume or sodium depletion 10) primary aldosteronism 11) symptomatic congestive heart failure 12) concurrent participation in another clinical trial 13) patients with known intolerance, contraindiciation or hypersensitivity to any component of dihydropyridines, angiotensin receptor blocker 14) patients who is judged not to be adequate by the investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24hr ambulatory mean pulse wave velocity | — |
Secondary
| Measure | Time frame |
|---|---|
| Change of 24hr ambulatory mean pulse wave velocity from randomization to 24wks;24hrs ambulatory morning, day, night pulse wave velocity at 24wks;Change of 24hr ambulatory morning, day, night pulse wave velocity from randomization to 24wks;24hr CBP (central blood pressure) at 24 wks;Change of 24hr CBP from randomization to24 wks;24hr AI (augmentation Index) at 24 wks;Change of 24hr AI from randomization to 24 wks;Ambulatory arterial stiffness index at 24 kws;Change of ambulatory arterial stiffness index from randomization to 24 wks;Change of microalbuminuria from randomization to 24 wks | — |
Countries
Korea, Republic of
Contacts
Public ContactByungsu Yoo
Yonsei University, Wonju Severance Christian Hospital
Outcome results
None listed