None listed
Conditions
Interventions
None listed
Sponsors
Kangwon National University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: ? suspected ischemic heart disease patient who will undergo coronary angiography a) previously healthy patient: no previous medical history with diagnosis of or treatment for coronary heart disease b) known ischemic heart disease patient: patient with new symptoms including chest pain, dyspnea, etc. within recent 1 month ? both male and female patients aged over 40
Exclusion criteria
Exclusion criteria: ? Severe renal failure, hepatic failure, brain function disorders, hypotension, cardiogenic shoke, or other physical or psycological problems that make the patient difficult to participate in the current study ? contraindications to adenosine or nicorandil as below: a) adenosine: hypersensitivity reaction, 2nd/3rd degree AV block, sick sinus syndrome, chronic obstructive pulmonary disease, long QT syndrome, severe hypotension, uncompensated heart failure, refractory unstable angina, dipyridamol use b) nicorandil: severe hepatic/renal dysfunction, severe brain dysfunction, severe hypotension or cardiogenic shock, Eisenmenger syndrome or primary hypertension, right ventricular infarction, dehydration symptoms, neurocirculatory asthenia, narrow angle glaucoma, history of hypersensitiveness to nicorandil or nitric acid/nitrite ester agents, use of phosphodiesterase-5 (PDE-5) or guanylate cyclase ? pregnancy or breast feeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| adverse effect: flushing, dyspnea, chest pain, gastrointestinal discomfort, headache, dizziness, hypotension, palpitation, weakness, nausea/vomiting, abdominal pain, back pain, toothache, nasal congestion, throat-neck discomfort, etc.;diagnostic performance for ischemic heart disease: sensitivity and specificity | — |
Secondary
| Measure | Time frame |
|---|---|
| Quantitative and semi-quantitative parameters from myocardial perfusion SPECT: left ventricular ejection fraction, myocardial blood flow udner rest (MBF-Re), myocardial blood flow udner stress (MBF-St), respectively), myocardial blood flow increasing rate (MBF-IR), sum of rest scores (SRS), sum of stress scores (SSS), sum of difference scores (SDS), etc. | — |
Countries
Korea, Republic of
Contacts
Public ContactIn Kook Chun
Kangwon National University Hospital
Outcome results
None listed