Autologous PRP treatment for refractory thin endometrium to enhance pregnancy and live birth rate

A pilot cohort study of autologous platelet-rich plasma in the treatment of unresponsive thin endometrium resistant to standard therapies

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0003385

Enrollment

100

Registered

2018-12-07

Start date

2016-01-11

Completion date

Unknown

Last updated

2019-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Biological/Vaccine, Non-Stem Cell : The subjects were treated with intrauterine infusion of autologous Platelet rich plasma (PRP) 2 or 3 times from menstrual cycle day 10 of their frozen-thawed embr

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: (a) age of 20?45 years at the time of enrollment, (b) endometrial thickness (EMT) of <7 mm on the human chorionic gonadotropin (hCG) administration day in fresh ET cycles or on the end of estrogen priming day in frozen ET cycles in all of the previous cycles, (c) two or more failed IVF cycles, (d) more than two cycles of previous therapy for increasing the EMT, such as, hysteroscopic adhesiolysis following hormone replacement therapy, high dose estradiol valerate, transvaginal sildenafil administration, or pentoxifyilline combination with vitamin E, (e) frozen embryo available for ET, and (f) informed consent form signed.

Exclusion criteria

Exclusion criteria: (a) hematologic disorders, hemoglobin level of <9.0 g/dL or platelet count of <100,000/µL, (b) auto-immune disease, (c) chromosomal abnormality in the patient or spouse, (d) peripheral NK cell proportion of =12%, (e) body mass index (BMI) of =30 kg/m2, and (f) uncontrolled endocrine or other medical conditions, such as prolactinemia or thyroid diseases

Design outcomes

Primary

Measure	Time frame
Live birth rate	—

Secondary

Measure	Time frame
clinical pregnancy day;Emdometrial thickness increment	—

Countries

Korea, Republic of

Contacts

Public ContactHounyoung Kim

Bundang CHA General Hospital

kyril98@chamc.co.kr+82-31-780-5200

Outcome results