Effect of IV dexmedetomidine on intraoperative stress reaction during trans-sphenoidal surgery: A randomized trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0003366

Enrollment

Registered

2018-11-21

Start date

2019-01-11

Completion date

Unknown

Last updated

2019-10-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : Dexmedetomidine: loading dose of 1.0 mcg/kg for 10 minutes, and then continuous infusion with a syringe pump at a rate of 0.2-0.7 mcg/kg/h until the start of the suture. 0.9&#37

saline: the same dose and same rate as dexmedetomidine is injected until the start of the suture.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Age=19 or >19 years old Patients undergoing pituitary tumor resection American Society of Anesthesiologist physical status I,II, III

Exclusion criteria

Exclusion criteria: American Society of Anesthesiologist physical status IV, V Age under 18 years old Age over 70 years old Pregnency unstable coronary artery disease, congestive heart failure, cardiomyopathy Cerebral disease Patient refusal Allergy to study drug Psychyatric disease Complete AV block, mild conduction delay, severe sinus bradycardia severe liver disease, severe renal insufficiency

Design outcomes

Primary

Measure	Time frame
Stress hormone concentrations	—

Secondary

Measure	Time frame
pain score;intraoperative blood pressure and heart rate;Cumulative opioid consumption at 24 hours postoperatively;perioperative sedation;Length of PACU stay	—

Countries

Korea, Republic of

Contacts

Public ContactRyungA Kang

Samsung Medical Center

ryunga.kang@gmail.com+82-2-3410-2470

Outcome results