None listed
Conditions
Interventions
Drug : Durvalumab 1500 mg of fixed dose via IV infusion q4w, starting on Week 0, for up to a total of 13 doses (4 doses as a combination, and then 9 doses as a monotherapy).
Tremelimumab 75 mg of fixe
Sponsors
Yonsei University Health System, Severance Hospital
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Written informed consent obtained from the subject prior to performing any protocol-related procedures, including screening evaluations 2. Pre or postmenopausal women with stage IV hormone receptor-positive breast cancer by histological or cytological confirmation 3. Age > 19 years at time of study entry 4. Progression after one line of any systemic therapy (endocrine, targeted or chemotherapy) in the metastatic setting 5. 2.1 or more nonsynonymous mutations per megabase (Mb) estimated by WES 6. Subject who has biopsy-accessible tumor 7. At least one measurable lesion by RECIST 1.1. Biopsied tumor may be counted a measurable lesion if it is not excised 8. Documented disease progression on the most recent therapy 9. Eastern Cooperative Oncology Group (ECOG) performance status of 0 ~ 1 10. Life expectancy of > 12 weeks 11. Adequate normal organ and marrow function as defined below: ? Haemoglobin = 9.0 g/dL ? Absolute neutrophil count (ANC) = 1.5 x 109/L (> 1500 per mm3) ? Platelet count = 100 x 109/L (>100,000 per mm3) ? Serum bilirubin = 1.5 x institutional upper limit of normal (ULN). This will not apply to subjects with confirmed Gilbert’s syndrome (persistent or recurrent hyperbilirubinemia that is predominantly unconjugated in the absence of hemolysis or hepatic pathology), who will be allowed only in consultation with their physician. ? AST (SGOT)/ALT (SGPT) = 2.5 x institutional upper limit of normal unless liver metastases are present, in which case it must be = 5x ULN ? Serum creatinine CL>40 mL/min by the Cockcroft-Gault formula (Cockcroft and Gault 1976) or by 24-hour urine collection for determination of creatinine clearance: Males: Creatinine CL (mL/min) = Weight (kg) x (140 – Age) . 72 x serum creatinine (mg/dL) Females: Creatinine CL (mL/min) = Weight (kg) x (140 – Age) x 0.85 72 x serum creatinine (mg/dL) 12. Female subjects must either be of non-reproductive potential (ie, post-menopausal by history: =60 years old and no menses for ?1 year without an alternative medical cause; OR history of hysterectomy, OR history of bilateral tubal ligation, OR history of bilateral oophorectomy) or must have a negative serum pregnancy test upon study entry. Otherwise, subjects must adhere to acceptable forms of birth control (a physician- approved contraceptive method: oral, injectable, or implantable hormonal contraceptive; intra-uterine device; barrier contraceptive with spermicide; or vasectomized partner). 13. Subject is willing and able to comply with the protocol for the duration of the study including undergoing treatment and scheduled visits and examinations including follow up.
Exclusion criteria
Exclusion criteria: 1. Involvement in the planning and/or conduct of the study (applies to both AstraZeneca staff and/or staff at the study site). Previous enrollment in the present study 2. Participation in another clinical study with an investigational product during the last 4 weeks 3. Any previous treatment with a PD1 or PD-L1 inhibitor, including durvalumab or an anti-CTLA-4, including tremelimumab 4. Previous or coexisting malignancies. However, malignancies that have been curatively treated >5 years prior to study entry can be included. Exceptionally, cervical cancer in-situ, basal cell carcinoma, papillary thyroid carcinoma and superficial bladder tumors (T1a and Tis) can be included anytime after curative treatment 5. Receipt of the last dose of anti-cancer therapy (chemotherapy, immunotherapy, endocrine therapy, targeted therapy, biologic therapy, tumor embolization, monoclonal antibodies, other investigational agent) = 21days prior to the first dose of study drug and within 6 weeks for nitrosourea or mitomycin C) for sufficient wash-out time 6. Palliative radiation, whole brain radiotherapy (WBRT), or gamma knife surgery (GKS) for brain metastases = 2 weeks prior to initiation of study medication. Major surgery = 4 weeks or minor surgery = 2 weeks prior to initiation of study medication. Majority or minority of surgery can be decided at the investigator’s discretion. Subjects who received these local therapy may be enrolled after predetermined time period 7. Mean QT interval corrected for heart rate (QTc) =470 ms calculated from 3 electrocardiograms (ECGs) using Fredericia’s Correction 8. Current or prior use of immunosuppressive medication within 28 days before the first dose of durvalumab or tremelimumab, with the exceptions of intranasal and inhaled corticosteroids or systemic corticosteroids at physiological doses, which are not to exceed 10 mg/day of prednisone, or an equivalent corticosteroid 9. Any unresolved toxicity (=CTCAE grade 2) from previous anti-cancer therapy. Subjects with irreversible toxicity that is not reasonably expected to be exacerbated by the investigational product may be included (e.g., hearing loss, peripherally neuropathy) 10. Any prior Grade =3 immune-related adverse event (irAE) while receiving any previous immunotherapy agent, or any unresolved irAE >Grade 1 11. Active or prior documented autoimmune disease within the past 2 years NOTE: Subjects with vitiligo, Grave’s disease, or psoriasis not requiring systemic treatment (within the past 2 years) are not excluded. 12. Active or prior documented inflammatory bowel disease (e.g., Crohn’s disease, ulcerative colitis) 13. History of primary immunodeficiency 14. History of allogeneic organ transplant 15. History of hypersensitivity to durvalumab or tremelimumab 16. Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, uncontrolled hypertension, unstable angina pectoris, cardiac arrhythmia, active peptic ulcer disease or gastritis, active bleeding diatheses including any subject known to have evidence of acute or chronic hepatitis A (anti-HAV antibody+), hepatitis B (HBs antigen+), hepatitis C (anti-HCV antibody+) or human immunodeficiency virus (HIV-1 or HIV-2 antibody+ or HTLV-1 antibody+), or psychiatric illness/social situations that would limit compliance with study requirements or compromise the ability of the subject to give written informed consent 17. Known hi
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Objective response rate (ORR) by RECIST 1.1 | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of response (DoR);Clinical benefit rate (CBR) by RECIST 1.1 defined by - complete or partial response or stable disease for at least 24 weeks;Disease control rate (DCR) by RECIST 1.1;Progression-free survival (PFS) by RECIST 1.1;Toxicity profile by NCI-CTCAE v4.03 | — |
Countries
Korea, Republic of
Contacts
Public ContactJoohyuk Sohn
Yonsei University Health System, Severance Hospital
Outcome results
None listed