None listed
Conditions
Interventions
Dietary Supplement : The test group was Weissella cibaria CMU (1.0 × 10 8 CFU / pack), and the control group is maltodextrin. One 1000 mg each is taken once a day in the mouth before sleeping and tak
Sponsors
Dankook University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Male and female aged 20 to over 70 2) A person with a score of 2 or more in the bad taste sensory evaluation (OLT) and a VSC concentration (H2S, CH3SH, (CH3) 2S) of 1.5ng or more 3) The person who agrees to participate in this test and who has voluntarily signed the written agreement (or legal representative)
Exclusion criteria
Exclusion criteria: 1) Those who are currently being treated or have a history of systemic disease (liver disease, renal disease, Sjogren's syndrome, rheumatic disease) that may cause bad breath (however, taking into consideration the condition of the subject, 2) Persons with severe dental disease (periodontal disease, dental caries, dry mouth) (dental caries in the dental caries test may be included in the test, except when more than one dental caries) 3) Those with uncontrolled hypertension (160 / 100mmHg or higher, after 5 minutes of test subjects ) 4) diabetic patients taking fasting blood glucose levels greater than 126 mg / dl, randomized blood glucose levels greater than 200 mg / dl, or taking oral hypoglycemic agents or insulin 5) AST (GOT) or ALT (GPT) blood pressure is three times higher than the normal upper limit of the institution 6) creatinine whose plasma level is more than twice the upper limit of normal level 7) Those taking antibiotics within 2 weeks before screening 8) Smokers 9) Those who complain of severe gastrointestinal symptoms such as heartburn and indigestion 10) Screening criteria Probiotic health functional foods within one week and those who consume fermented milk continuously (more than 4 times a week) 11) Those who are pregnant, breastfeeding, or who have a pregnancy plan during the study period 12) Applicable to human body Any person who is sensitive or allergic to food related food 13) Those who intend to participate in other tests during this human body application test. 14) Those who participated in another human body test within 4 weeks 15) A person who is deemed by the tester to be unsuitable for this human body test
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Volatile sulfur compound concentrationby Oralchroma | — |
Secondary
| Measure | Time frame |
|---|---|
| Organoleptic halitosis check;tongue plaque;simplified oral hygiene index;simplified oral hygiene index;gingival index | — |
Countries
Korea, Republic of
Contacts
Public ContactEUNSIM KIM
Dankook University Dental Hostipal
Outcome results
None listed