Population pharmacokinetic analysis and analgesic potency of fentanyl

Population pharmacokinetic analysis and analgesic potency of fentanyl to achieve individualized dosing strategy of intravenous patient-controlled analgesia in patients undergoing major abdominal surgeries.

Status

Recruiting

Phases

Phase 1

Study type

Interventional

Source

CRIS

Registry ID

KCT0003273

Enrollment

Registered

2018-10-18

Start date

2018-11-12

Completion date

Unknown

Last updated

2019-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Others : 1. Intravenous fentanyl 100 µg injection before skin incision 2. Using the measurement of minimal effective concentration and minimal effective analgesic concentration of fentanyl

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients undergoing elective surgery 2. Age: >or = 20 3. Patients under general anesthesia for abdomoinal surgery at E rosette in Asan Medical Center 4. Patients who signed a written informed consent form

Exclusion criteria

Exclusion criteria: 1. Hemoglobin < 9 g/dl 2. Clinically impaired cardiovascular, respiratory, hepatobilliary and renal function 3. Ejection fraction < 50% on echocardiography 4. Liver cirrosis 5. Alanine aminotransferase < 100 IU/L 6. Glomerular filtration rate < 60 ml/min 7. Patients who are considered by the investigator to be unsuitable to participate in the study for any other reason not mentioned in the inclusion and exclusion criteria

Design outcomes

Primary

Measure	Time frame
Volumnof distribution and plasma clearance rate of fentanyl at preset intervals;minimum effective concentration and minimum effective analgesic concentration of fentanyl	—

Secondary

Measure	Time frame
area aunter the curve	—

Countries

Korea, Republic of

Contacts

Public ContactMiyoung Kwon

National Medical Center

miyoung.kwon@nmc.or.kr+82-2-2276-2367

Outcome results