Short-term Effect of Combined rTMS and Action Observation on Recovery of Upper Extremity Function in Stroke Patients: A Randomized Controlled Trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0003200

Enrollment

Registered

2018-09-20

Start date

2012-09-01

Completion date

Unknown

Last updated

2019-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Others(Combined action observation and rTMS) : Patients were identified by a number assigned by a centralized computer-generated randomization code. The patients were randomly allocated to one of the

s head and placed using standard anatomical markers along the nasion to inion line and the interaural line. The coil was kept tangential to the scalp and maintained at 45 ° in the mid-sagittal line. T

50uV in ten consecutive trials (Rossini et al., 1994). Both groups received 1 Hz rTMS (intensity, 120&#37

of rMT) over contralesional primary motor cortex (M1) for 20 minutes for 10 consecutive weekdays. Subjects were instructed to sit in a comfortable chair with both hands placed on its armrests in a rel

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria for these patients were as follows: (1) patients aged 18 years or older, (2) patients with first-ever stroke, (3) patients who have a unilateral vascular stroke lesion in the cerebral hemisphere as confirmed by computed tomography (CT) or magnetic resonance imaging (MRI) scans, (4) patients who have a mild to moderate unilateral hemiparesis secondary to cerebrovascular accident (finger movements are more than fair grade and individual finger movement is possible) (5) patients who are able to follow simple verbal commands or instructions (no severe deficit in visual, attentional and language comprehension), (6) patients who had a MEP response performed in the paralyzed hand (excluded when TMS of 100% intensity could not induce MEP response)

Exclusion criteria

Exclusion criteria: Exclusion criteria included lesion of bilateral cerebral hemisphere, or brain stem, and known history of previous stroke. Patients who had cognitive impairment that prevent them from following test instructions given by medical staff, presence of unstable medical conditions, peripheral neuropathy that might affect MEPs responses and contraindications to TMS (seizure, cardiac pacemaker or coil embolization).

Design outcomes

Secondary

Measure	Time frame
side effects	—

Primary

Measure	Time frame
upper extremity motor function	—

Countries

Korea, Republic of

Contacts

Public ContactJun Soo Noh

Korea University Anam Hospital

nojoonsoo@hanmail.net+82-2-920-6471

Outcome results