None listed
Conditions
Interventions
None listed
Sponsors
Konkuk University Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1)Patients with Dementia due to AD or MCI due to AD (intermediate to high biomarker probability) according to the NIA-AA diagnostic guidelines (2011).Informed consent before participation in the study 2)In case of patient with dementia, Clinical dementia rating (CDR) of 0.5 or 1, which means a mild stage of dementia 3)Age of 45-80 4)Informed consent understood, signed and patient agrees to all follow-up visits.
Exclusion criteria
Exclusion criteria: 1) Contraindications for scanning (e.g. brain surgery, cardiac pacemaker, metal implants, claustrophobia, large body tattoos) 2) Contraindications for contrast agent Gadovist (renal failure) as determined by the estimated Glomular Filtration Rate eGFR < 30 mL/min. 3) Major vascular disorders (e.g. stroke, heart disease) 4) Psychiatric or neurological disorders: Major depression (< 12 months); history of schizophrenia; bipolar disorder; psychotic disorder NOS or treatment for a psychotic disorder (< 12 months); cognitive impairment due to alcohol abuse; epilepsy; Parkinson's disease; MS; brain surgery; brain trauma; electroshock therapy; kidney dialysis; Meniere's disease; and brain infections. 5) Structural abnormalities of the brain 6) Cognitive impairment due to alcohol/drug abuse 7) Absence of reliable informant (for patient groups)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood brain barrier permeability as measured by T1-weighted DCE MRI | — |
Secondary
| Measure | Time frame |
|---|---|
| temporal change of blood brain barrier permeability as measured by T1-weighted DCE MRI | — |
Countries
Korea, Republic of
Contacts
Public ContactSuji Kim
Konkuk University Medical Center
Outcome results
None listed