None listed
Conditions
Interventions
Drug : Hyperinsulinemic-euglycemic clamp testing after a 10-hour fast was performed within 1 week following the oral glucose tolerance test (OGTT) in healthy adult male subjects with normal glucose to
Eli Lilly and Co., Indianapolis, IN, USA) was infused at a rate of 10 mU/m2·min for 100 min, and then a high dose of insulin (80 mU/m2·min) was applied for 100 min to suppress hepatic glucose producti
dextrose solution was administered to maintain euglycemia, and the plasma glucose levels were measured every 5 min. During the last 20 min at steady state with the plasma glucose level being maintaine
Sponsors
Gachon University Gil Medical Center
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1) Korean aged 50-69 years old 2) body weight 50kg or more with body mass index (kg/m2) 18.5-28 3) no congenital or systemic illnesses requiring medical care 4) no significant abnormal results on screening tests which included routine blood test and blood chemistry, urine test, ECG and physical examinations 5) subjects who provided written informed consent
Exclusion criteria
Exclusion criteria: 1) Subjects with impaired fasting glucose, impaired glucose tolerance, or diabetes or subjects on medical therapy for diabetes 2) Subjects who have hypersensitivity to insulin or preservatives of insulin 3) Subjects with specific diseases in hepatobiliary, renal, or cardiovascular systems, with endocrine disease, or with other systemic illnesses 4) active liver diseases or liver transaminase enzyme levels elevated more than twofold the upper limit of normal 5) patients with known hypertension or subjects with blood pressure levels of > 160/90 mmHg or < 90/60 mmHg. 6) systemic diseases or injury within 12 weeks 7) other study medication or intervention therapy within 3 months before oral glucose tolerance test 8) Positive result on tests for HBs antigen, HCV antibody, or HIV antibody 9) any other issue suggesting that study participation seems to be inappropriate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| glucose disposal rate (mg/kg/min) | — |
Secondary
| Measure | Time frame |
|---|---|
| 2 hour-glucose level after oral glucose loading (75grams) | — |
Countries
Korea, Republic of
Contacts
Public ContactDAE HO LEE
Gachon University Gil Medical Center
Outcome results
None listed