None listed
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1) Age 20-65 years 2) Body mass index (BMI) more than 23.0 kg/m² (overweight or obese for Asian populations, according to the World Health Organization)
Exclusion criteria
Exclusion criteria: 1) Participants with weight gain more than 5kg in the last 3 months 2) Participants with history of bariatric surgery 3) Participants with secondary obesity, such as hypothyroidism 4) Participants with uncontrolled hypertension or type 1 diabetes 5) Participants who are taking anti-diabetic medications due to type 2 diabetes 6) Participants with hepatic disease (AST or ALT =200 mg/dL) 7) Participants with renal disease (serum creatinine =2.0 mg/dL) 8) Participants with pancreatitis or related disorders 9) Participants with acute infectious diseases (i.e., pneumonia, acute enteritis, or urinary infection) 10) Participants with chronic inflammatory diseases (i.e., rheumatoid arthritis, or lupus) 11) Participants with overeating behavior 12) Participants with history of cardiovascular diseases 13) Participants with history of cancer 14) Participants who are taking anti-obesity, anti-diabetic, diuretic, central-nervous system, antidepressant, antipsychotic, or steroid medications 15) Pregnant or lactating women 16) Participants who intake more than 30 g of alcohol daily 17) Night-time or shift-work workers 18) Participants with chronic malabsorption syndrome or cholestasis 19) Participants with other medical conditions that would preclude subjects from participating in exercise and physical test
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in body weight | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in body composition (fat mass, muscle mass, visceral fat, subcutaneus fat);Change in metabolic parameters (fasting glucose, insulin, triglyceride, HDL-cholesterol, LDL-cholesterol) | — |
Countries
Korea, Republic of
Contacts
Yonsei University Health System, Gangnam Severance Hospital