None listed
Conditions
Interventions
None listed
Sponsors
Gachon University Gil Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: .- Subjects who provided written informed consent - Aged 19-70 years - those suspected of having NAFLD and belong to one of the followings: who planned to receive liver biopsy or who received liver biopsy for NAFLD within the past 3 months, NAFLD fibrosis score > 0.675, or liver stiffness on FibroScan > 7.5 kPa - no congenital or systemic illnesses requiring specific treatment except for NAFLD - Those seemed appropriate for study participation on screening tests involving medical history, physical examinations, blood cell test, serum/plasma biochemistry, and urine analysis - Healthy adult subjects aged between 19 and 70 years as normal control subjects
Exclusion criteria
Exclusion criteria: - Aged less than 19 years or more than 70 years - Pregnancy - Drug abusers - Alcohol drink > 30 g/day (about 3 unit/day) in male and > 20 g/day (about 2 unit/day) in female during the last 5 years - Contraindications to MRI examination - Other liver diseases except for NAFLD - Liver cirrhosis with ascites or biliary tract diseases - Medications causing fatty liver (e.g., corticosteroids, tamoxifen, amiodarone, methotrexate and others) - Other systemic diseases seemed to be inappropriate for study participation - Inappropriate for study participation at the discretion of attending physicians
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Correlation between the grade of fibrosis on liver biopsy and liver stiffness measurement (LSM) on MR elastography (MRE);Correlation between MRE-LSM and clinical scores of liver fibrosis (e.g., non-alcoholic fatty liver disease fibrosis score and Fibrosis-4) | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation between Liver fat content on MRI-proton density fat fraction (MRI-PDFF) and fat content grade on liver biopsy;Correlation between fat content values MRI-PDFF and MRS methods;The cut-off values of MRE-LSM corresponds to fibrosis stage F3 on liver biopsy;Factors correlate well with MRE-LSM values;Comparisons between group with high grade liver fibrosis and group without hepatic fibrosis (epigenetic and genetic profiles and fecal microbiota) | — |
Countries
Korea, Republic of
Contacts
Public ContactDAE HO LEE
Gachon University Gil Medical Center
Outcome results
None listed