Effect of dexmedetomidine on postoperative cognitive function in elderly patients after robot-assisted radical prostatectomy

Effect of dexmedetomidine on postoperative cognitive function and perioperative inflammation in elderly patients after robot-assisted radical prostatectomy

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CRIS

Registry ID

KCT0003080

Enrollment

Registered

2018-08-09

Start date

2018-08-10

Completion date

Unknown

Last updated

2019-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : After induction of anesthesia, dexmedetomidine is administered at a rate of 0.4 mcg / kg / h, which is administered intravenously 30 minutes before the end of the operation.

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: Patients older than 60 years undergoing robot assisted radical prostatectomy who have no other psychiatric disorders except dementia and who are normal healthy patients or patients with mild systemic disease.

Exclusion criteria

Exclusion criteria: Patients with severe systemic disease, patients with allergies to dexmedetomidine, patients who are unable to communicate or impaired cognitive function, patients who can not read the consent form (eg illiterate, foreigner)

Design outcomes

Primary

Measure	Time frame
MMSE score	—

Secondary

Measure	Time frame
TNF-a (Tumor Necrosis Factor-a);IL-6 (Interleukin 6);NSE (neuron-specific enolase);CRP (C-reactive protein);HMGB1(High mobility group box 1)	—

Countries

Korea, Republic of

Contacts

Public ContactHyun Jeong Lee

Eulji University Medical Center

ioui0819@hanmail.net+82-2-970-8084

Outcome results