None listed
Conditions
Interventions
Drug : Treatment group : GyejigaChulBuTang(GCB), po-med, 3times/day 30min after meal, 1times 1shot(2.5g) total 3shot(7.5g), 28days medication
Control group : Placebo(lactose, starch, caramel pigment),
Sponsors
Dunsan Korean Medicine Hospital of Daejeon University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients over 40 years old 2. A person who complains of more than VAS 30 mm of pain in his knee during his or her daily life. 3. Over grade 2 on Kellgren-Lawrence Grading Scale 4. A person who voluntarily decides to participate and agrees to the written agreement after having received a full explanation of the research objectives and processes
Exclusion criteria
Exclusion criteria: 1. Person with severe knee trauma in the last 6 months 2. Person with medical history of knee or planning for surgery within the research period 3. Person who received injection treatment such as steroids within 3 months and hyaluronic acid within 6 months 4. Person with a history of acupuncture, herbal acupuncture and herbal medicine for knee pain relief within the last month 5. Screening Clinical Examination ESR > 40 mmh, 1. RA Factor>20U/mL 6. Persons with musculoskeletal problems that cause more pain than knee pain in other body parts 7. If you have an uncontrolled heart condition such as angina, congestive heart failure, or if your blood test results in liver(AST, ALT levels are 40 Ul or higher), and the kidney function is abnormal(Creatine 0.5-0.9mg/dl, BUN 6-20mg/dl), systolic blood pressure is at least 180m mmg or greater than 100m mm even after two or three repeated measurements 8. People who are pregnant, nursing or diagnosed with malignant tumors 9. Galactose intolerance, lappase lactase deficiency, or glucose deficiency 10. A neuropsychiatrics who has significant history or is currently ill 11. Other members of the clinical research team think they are unsuitable
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS | — |
Secondary
| Measure | Time frame |
|---|---|
| K-WOMAC;PGIC(Patient Global Impression of change);Adverse event | — |
Countries
Korea, Republic of
Contacts
Public ContactEunseok Kim
Dunsan Korean Medicine Hospital of Daejeon University
Outcome results
None listed