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Prospective study of midazolam for preventing postoperative nausea and vomiting in patients following laparoscopic benign gynecological surgery

Comparison of ondansetron with combined ondansetron and midazolam for preventing postoperative nausea and vomiting in patients following laparoscopic benign gynecological surgery

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CRIS
Registry ID
KCT0002930
Enrollment
144
Registered
2018-06-17
Start date
2018-06-29
Completion date
Unknown
Last updated
2019-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

None listed

Sponsors

Bundang CHA General Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: Adults of American Society of Anesthesiologists’ physical status 1 or 2 undergoing laparoscopic gynaecological surgery, Age of 19-65

Exclusion criteria

Exclusion criteria: Adults of American Society of Anesthesiologists’ physical status 3 or more, who have allergy with ondansetron or midazolam, who had history of taken chemotherapy, chronic use of opioids or alcohol. Decreased liver or kidney function, conversion to open surgery pregnancy or breast-feeding, obesity Patients with diabetes mellitus or gastrointestinal disease, and those who had taken an antiemetic medication 24 h before surgery

Design outcomes

Primary

MeasureTime frame
Complete response up to 48 h after surgery. Complete response was defined as no PONV and no rescue antiemetics—

Secondary

MeasureTime frame
incidence of nausea, incidence of severe nausea (mild (1–3), moderate (4–6), and severe (7–10)), incidence of vomiting, additional use of rescue antiemetics—

Countries

Korea, Republic of

Contacts

Public ContactJiyoung Lee

Bundang CHA General Hospital

leejiyoung0616@gmail.com+82-31-780-1838

Outcome results

None listed

Source: CRIS (via WHO ICTRP) · Data processed: Feb 4, 2026